Year 2021 / Volume 113 / Number 2
Review
Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis

125-135

DOI: 10.17235/reed.2020.7397/2020

Javier Ampuero, Yolanda Sánchez, María Rosario García-Lozano, Douglas Maya-Miles, Manuel Romero Gómez,

Abstract
Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact of baseline liver function (aspartate aminotransferase [AST], alanine aminotransferase [ALT], bilirubin) on COVID-19-related outcomes, including mortality, intensive care unit (ICU) admissions, and non-fatal severe complications. Methods: after a systematic review of the relevant studies the odds ratio (OR), mean difference, sensitivity, specificity, and both positive and negative likelihood ratios were calculated for the prediction of relevant COVID-19 outcomes by performing a meta-analysis using fixed and random effects models. A Fagan nomogram was used to assess clinical usefulness. Heterogeneity was explored by sensitivity analysis and univariate meta-regression. Results: twenty-six studies were included (22 studies and 5,271 patients for AST, 20 studies and 5,440 subjects for ALT, and nine studies and 3,542 patients for bilirubin). The outcomes assessed by these studies were: survival (n = 8), ICU admission (n = 4), and non-fatal severe complications (n = 16). AST > upper limit of normal (ULN) (OR: 3.10 [95 % CI, 2.61-3.68]), ALT > ULN (OR: 2.15 [95 % CI, 1.43-3.23]), and bilirubin > ULN (OR: 2.78 [95 % CI, 1.88-4.13]) were associated with an increased prevalence of severe complications with a specificity of 78 %, 77 %, and 94 %, respectively. The mean difference between mild and severe COVID-19 was 10.7 U/l (95 % CI, 5.8-15.6) for AST, 8 U/l (95 % CI, 1.0-15) for ALT, and 0.3 mg/dl (95 % CI, 0.16-0.45) for bilirubin. Conclusions: patients showing liver injury had a significantly higher risk of developing severe COVID-19 as compared to those with normal liver function tests at admission. We should include the assessment of AST, ALT, and total bilirubin (TB) routinely in the workup of patients affected by SARS-CoV-2 in order to predict those at risk of developing COVID-19-related outcomes.
Share Button
New comment
Comments
No comments for this article
References
1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733.
2. Crespo J, Iglesias-Garcia J, Hinojosa J, et al. COVID-19 and the Digestive System: Protection and Management During the SARS-CoV-2 Pandemic. Rev. Esp. Enferm. Dig. 2020;112
3. Liu PP, Blet A, Smyth D, et al. The Science Underlying COVID-19: Implications for the Cardiovascular System. Circulation 2020;
4. Hussain A, Bhowmik B, Cristina do Vale Moreira N. COVID-19 and Diabetes: Knowledge in Progress. Diabetes Res. Clin. Pract. 2020;108142.
5. Wu P, Duan F, Luo C, et al. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;
6. Su C-J, Lee C-H. Viral exanthem in COVID-19, a clinical enigma with biological significance. J. Eur. Acad. Dermatol. Venereol. 2020;
7. Xiong M, Liang X, Wei Y. Changes in Blood Coagulation in Patients with Severe Coronavirus Disease 2019 (COVID‐19): a Meta‐Analysis. Br. J. Haematol. 2020;bjh.16725.
8. Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. Gastroenterology 2020;
9. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395:1033–1034.
10. Zhu J, Ji P, Pang J, et al. Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis. J. Med. Virol. 2020;
11. Henry BM, Oliveira MHS de, Benoit S, et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin. Chem. Lab. Med. 2020;
12. Cai Q, Huang D, Yu H, et al. Characteristics of Liver Tests in COVID-19 Patients. J. Hepatol. 2020;
13. Ji D, Qin E, Xu J, et al. Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study. J. Hepatol. 2020;
14. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann. Intern. Med. 2009;151:264–269.
15. Hayden JA, Côté P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann. Intern. Med. 2006;144:427–437.
16. Higgins JPT, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. Br. Med. J. 2003;327:557–560.
17. Copas JB, Shi JQ. A sensitivity analysis for publication bias in systematic reviews. Stat. Methods Med. Res. 2001;10:251–265.
18. Petitti DB. Approaches to heterogeneity in meta-analysis. Stat. Med. 2001;20:3625–33.
19. Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020;
20. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;
21. Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020;
22. Bangash MN, Patel J, Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol. Hepatol. 2020;
23. Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol. Hepatol. 2020;5:428–430.
24. Chai X, Hu L, Zhang Y, et al. Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection. bioRxiv 2020;2020.02.03.931766.
25. Feng G, Zheng KI, Yan Q-Q, et al. COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. J. Clin. Transl. Hepatol. 2020;8:18–24.
26. Boeckmans J, Rodrigues RM, Demuyser T, et al. COVID-19 and drug-induced liver injury: a problem of plenty or a petty point? Arch. Toxicol. 2020;
27. Wynants L, Calster B Van, Bonten MMJ, et al. Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. BMJ 2020;369:m1328.
28. Munster VJ, Koopmans M, Doremalen N van, et al. A novel coronavirus emerging in China - Key questions for impact assessment. N. Engl. J. Med. 2020;382:692–694.
29. Fan Z, Chen L, Li J, et al. Clinical Features of COVID-19-Related Liver Damage. Clin. Gastroenterol. Hepatol. 2020;
30. Xie H, Zhao J, Lian N, et al. Clinical characteristics of Non-ICU hospitalized patients with coronavirus disease 2019 and liver injury:A Retrospective study. Liver Int. 2020;
31. Sun D, Li H, Lu X-X, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J. Pediatr. 2020;
32. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507–513.
33. Lippi G, Oliveira MHS de, Henry BM. Chronic liver disease is not associated with severity or mortality in Coronavirus disease 2019 (COVID-19). Eur. J. Gastroenterol. Hepatol. 2020;1.
34. Fu L, Wang B, Yuan T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. J. Infect. 2020;
35. Gong J, Ou J, Qiu X, et al. A Tool to Early Predict Severe Corona Virus Disease 2019 (COVID-19) : A Multicenter Study using the Risk Nomogram in Wuhan and Guangdong, China. Clin. Infect. Dis. 2020;
36. Zhang J, Wang X, Jia X, et al. Risk factors for disease severity, unimprovement, and mortality of COVID-19 patients in Wuhan, China. Clin. Microbiol. Infect. 2020;
37. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020;
38. Li Y-K, Peng S, Li L-Q, et al. Clinical and Transmission Characteristics of Covid-19 — A Retrospective Study of 25 Cases from a Single Thoracic Surgery Department. Curr. Med. Sci. 2020;
39. Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020;368:m1091.
40. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;
41. Cao J, Tu W-J, Cheng W, et al. Clinical Features and Short-term Outcomes of 102 Patients with Corona Virus Disease 2019 in Wuhan, China. Clin. Infect. Dis. 2020;
42. Guan W, Ni Z, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med. 2020;
43. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506.
44. Zhang G, Zhang J, Wang B, et al. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A retrospective analysis. Respir. Res. 2020;21
45. Du R-H, Liu L-M, Yin W, et al. Hospitalization and Critical Care of 109 Decedents with COVID-19 Pneumonia in Wuhan, China. Ann. Am. Thorac. Soc. 2020;
46. Zhang Y, Zheng L, Liu L, et al. Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city, China. Liver Int. 2020;
47. Wan S, Xiang Y, Fang W, et al. Clinical features and treatment of COVID-19 patients in northeast Chongqing. J. Med. Virol. 2020;
48. Wang Z, Yang B, Li Q, et al. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin. Infect. Dis. 2020;
49. Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect. Dis. 2020;20:425–434.
50. Cai Q, Huang D, Ou P, et al. COVID-19 in a Designated Infectious Diseases Hospital Outside Hubei Province, China. Allergy 2020;
51. Zheng F, Tang W, Li H, et al. Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur. Rev. Med. Pharmacol. Sci. 2020;24:3404–3410.
52. Li L, Li S, Xu M, et al. Risk factors related to hepatic injury in patients with corona virus disease 2019. medRxiv 2020;
53. Li X, Xu S, Yu M, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J. Allergy Clin. Immunol. 2020;
54. Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;
55. Zhang X, Cai H, Hu J, et al. Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings. Int. J. Infect. Dis. 2020;
56. Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;
57. Liu Y, Du X, Chen J, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J. Infect. 2020;
58. Meng H, Xiong R, He R, et al. CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China. J. Infect. 2020;
59. Zheng Y, Xu H, Yang M, et al. Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. J. Clin. Virol. 2020;127:104366.
60. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008-2012.
Related articles

Editorial

Early liver transplantation in severe alcohol-associated hepatitis

DOI: 10.17235/reed.2024.10881/2024

Editorial

Lights and shadows in the new definition of steatotic liver disease

DOI: 10.17235/reed.2024.10696/2024

Letter

Abernethy syndrome as a cause of liver transplantation

DOI: 10.17235/reed.2024.10561/2024

Letter

A ghost epigastric pain

DOI: 10.17235/reed.2024.10500/2024

Letter

IgG4-related disease mimicking a liver abscess

DOI: 10.17235/reed.2024.10265/2024

Letter

Mixed crawling-type gastric adenocarcinoma

DOI: 10.17235/reed.2024.10205/2023

Letter

Treatment with hyperbaric oxygen in a Crohn’s disease patient

DOI: 10.17235/reed.2024.10166/2023

Letter

Fatal HBV-liver failure after withdrawal of antiviral treatment

DOI: 10.17235/reed.2024.10115/2023

Letter

Jejunal gastrointestinal stromal tumor: a diagnostic challenge

DOI: 10.17235/reed.2024.10108/2023

Letter

Gastric bronchogenic cyst

DOI: 10.17235/reed.2023.9964/2023

Letter

Ileal metastasis from phyllodes breast tumor

DOI: 10.17235/reed.2023.9958/2023

Letter

A case of complex hemangioendothelioma of the liver in an infant

DOI: 10.17235/reed.2023.9949/2023

Letter

Gastric schwannoma diagnosing gastric stromal tumor

DOI: 10.17235/reed.2023.9919/2023

Letter

Repeated endoscopic treatment of gastric antral vascular ectasia

DOI: 10.17235/reed.2023.9917/2023

Letter

Blue rubber bleb nevus syndrome

DOI: 10.17235/reed.2023.9913/2023

Letter

Spontaneous cystogastric fistula: an accidental discovery

DOI: 10.17235/reed.2023.9912/2023

Digestive Diseases Image

Extremely giant liver hemangioma: a case beyond the norms

DOI: 10.17235/reed.2023.9877/2023

Digestive Diseases Image

Enteroenteric intussusception caused by a small bowel metastatic cutaneous melanoma

DOI: 10.17235/reed.2023.9876/2023

Letter

Gastric cardia bronchogenic cyst with prolonged belching

DOI: 10.17235/reed.2023.9865/2023

Letter

Drug-induced liver injury associated to red yeast rice

DOI: 10.17235/reed.2023.9797/2023

Letter

An unusual cause of liver lesions

DOI: 10.17235/reed.2023.9787/2023

Editorial

Diagnosis and management of Abernethy syndrome

DOI: 10.17235/reed.2023.9781/2023

Letter

Upper gastrointestinal bleeding and Rigler triad

DOI: 10.17235/reed.2023.9731/2023

Letter

Gastric duplication cyst with peristalsis

DOI: 10.17235/reed.2023.9721/2023

Letter

Surgical indication of type I gastric neuroendocrine tumors

DOI: 10.17235/reed.2023.9681/2023

Letter

Endoscopic rescue of a fistulizing biliary plastic stent

DOI: 10.17235/reed.2023.9673/2023

Letter

Amyloidosis: a rare cause of severe acute liver failure

DOI: 10.17235/reed.2023.9598/2023

Letter

MALT lymphoma of the colon: an endoscopic challenge

DOI: 10.17235/reed.2023.9595/2023

Letter

Icteric syndrome secondary to polycystic liver disease

DOI: 10.17235/reed.2023.9590/2023

Letter

Autoimmune hepatitis after SARS-C¬¬oV-2 vaccination

DOI: 10.17235/reed.2023.9579/2023

Letter

The role of gastrointestinal endoscopy in Kaposi sarcoma

DOI: 10.17235/reed.2023.9534/2023

Letter

Liver disorders and celiac disease

DOI: 10.17235/reed.2023.9516/2023

Digestive Diseases Image

Gastric calcinosis ulcer in a renal transplanted patient

DOI: 10.17235/reed.2023.9495/2023

Letter

Recurrence of gastric schwannoma

DOI: 10.17235/reed.2023.9480/2023

Letter

Intestinal pneumatosis as a manifestation of systemic sclerosis

DOI: 10.17235/reed.2023.9428/2022

Digestive Diseases Image

Type II achalasia with post-POEM recovery of esophageal motility

DOI: 10.17235/reed.2023.9420/2022

Editorial

A new year and a new roadmap for the journal in challenging times

DOI: 10.17235/reed.2022.9372/2022

Digestive Diseases Image

Germ cell tumor with duodenal involvement: a rare case of gastrointestinal bleeding

DOI: 10.17235/reed.2022.9327/2022

Letter

Vaginal lesion as first manifestation of colorectal disease

DOI: 10.17235/reed.2022.9270/2022

Letter

Budd-Chiari syndrome in Behçet’s disease

DOI: 10.17235/reed.2022.9267/2022

Letter

An unexpected gastric cardia submucosal lesion

DOI: 10.17235/reed.2022.9260/2022

Letter

A rare endoscopic finding: primary esophageal melanoma

DOI: 10.17235/reed.2022.9244/2022

Digestive Diseases Image

Black esophagus

DOI: 10.17235/reed.2022.9217/2022

Digestive Diseases Image

Endosonographic and ERCP findings in COVID-19 critical illness cholangiopathy

DOI: 10.17235/reed.2022.9218/2022

Digestive Diseases Image

Intrabiliary metastasis of colorectal adenocarcinoma: the SPY perspective

DOI: 10.17235/reed.2022.9202/2022

Letter

Primary gastric leiomyosarcoma presenting as a giant polyp

DOI: 10.17235/reed.2022.9165/2022

Letter

A rare cause of obscure gastrointestinal bleeding

DOI: 10.17235/reed.2022.9156/2022

Digestive Diseases Image

A rare endoscopic pattern in a patient with gastroesophageal reflux disease

DOI: 10.17235/reed.2022.9124/2022

Digestive Diseases Image

The sentinel polyp: high-grade sarcoma revealed after colonic polypectomy

DOI: 10.17235/reed.2022.9093/2022

Letter

Weil syndrome coincident with upper gastrointestinal bleeding

DOI: 10.17235/reed.2022.9086/2022

Letter

A full hemostatic repertoire in a complex cirrhotic patient

DOI: 10.17235/reed.2022.9039/2022

Letter

Hemostasis of a bleeding inverted colonic diverticulum

DOI: 10.17235/reed.2022.9019/2022

Letter

Sepsis due to phlegmonous gastritis in a cancer patient

DOI: 10.17235/reed.2022.9009/2022

Editorial

Drug induced liver injury by immunotherapy

DOI: 10.17235/reed.2022.9179/2022

Letter

GIST is not all that it seems

DOI: 10.17235/reed.2022.8974/2022

Letter

Infection with SARS-CoV-2 as a potential achalasia trigger

DOI: 10.17235/reed.2022.8975/2022

Letter

Primary intestinal melanoma?

DOI: 10.17235/reed.2022.8944/2022

Letter

Intestinal amyloidosis: a diagnostic challenge

DOI: 10.17235/reed.2022.8934/2022

Letter

Epithelioid angiomyolipoma of the liver: an incidental diagnosis

DOI: 10.17235/reed.2022.8895/2022

Letter

Intra-abdominal epithelioid angiosarcoma

DOI: 10.17235/reed.2022.8878/2022

Review

Immunotherapy in hepatocellular carcinoma

DOI: 10.17235/reed.2022.8876/2022

Letter

Retracted articles in Gastroenterology

DOI: 10.17235/reed.2022.8859/2022

Digestive Diseases Image

An unusual finding in gastroesophageal surgery: gastric anthracosis

DOI: 10.17235/reed.2022.8882/2022

Digestive Diseases Image

Acute respiratory failure secondary to megaesophagus: think beyond COVID-19

DOI: 10.17235/reed.2022.8847/2022

Digestive Diseases Image

Gastrointestinal infection by Mycobacterium avium with an unusual endoscopic presentation

DOI: 10.17235/reed.2022.8845/2022

Letter

A rare cause of a bulging mass in the mid esophagus

DOI: 10.17235/reed.2022.8834/2022

Editorial

Chronic intestinal failure: an overview and future perspectives

DOI: 10.17235/reed.2022.8827/2022

Letter

SARS-CoV-2 vaccine, a new autoimmune hepatitis trigger?

DOI: 10.17235/reed.2022.8820/2022

Digestive Diseases Image

An unusual cause of a protuberant lesion of the gastric antrum

DOI: 10.17235/reed.2022.8771/2022

Letter

Analysis of retracted articles in the field of Gastroenterology

DOI: 10.17235/reed.2022.8760/2022

Digestive Diseases Image

Liver abscess due to parvimonas micra

DOI: 10.17235/reed.2022.8751/2022

Letter

Surgical acute abdomen and COVID-19 vaccination

DOI: 10.17235/reed.2022.8721/2022

Digestive Diseases Image

Colonic Kaposi’s sarcoma as the first clinical manifestation of undiagnosed HIV

DOI: 10.17235/reed.2022.8717/2022

Letter

A rare gastrointestinal tumor: primary gastric melanoma

DOI: 10.17235/reed.2022.8715/2022

Digestive Diseases Image

When needles are not enough, forceps delivers!

DOI: 10.17235/reed.2022.8697/2022

Letter

A large perforated gastric ulcer due to cocaine use

DOI: 10.17235/reed.2022.8676/2022

Digestive Diseases Image

Posterior reversible encephalopathy syndrome (PRES) in post liver transplantation

DOI: 10.17235/reed.2022.8694/2022

Digestive Diseases Image

Ileal neuroendocrine tumor as an uncommon cause of obscure gastrointestinal bleeding

DOI: 10.17235/reed.2022.8641/2022

Editorial

Acute pancreatitis: an opportunity for gastroenterology hospitalists?

DOI: 10.17235/reed.2022.8573/2022

Letter

AMA-positive hepatitis induced by the SARS-CoV-2 vaccine.

DOI: 10.17235/reed.2022.8533/2021

Letter

Gastric ulcer with liver penetration

DOI: 10.17235/reed.2022.8528/2021

Letter

Ertapenem neurotoxicity in liver transplantation

DOI: 10.17235/reed.2021.8469/2021

Digestive Diseases Image

Crack cocaine abuse as an undescribed cause of gastric outlet obstruction

DOI: 10.17235/reed.2022.8438/2021

Digestive Diseases Image

Ischemic cholangiopathy following hepatic artery pseudoaneurysm with thrombosis

DOI: 10.17235/reed.2021.8395/2021

Letter

A case of COVID-19 with concomitant infection with hepatitis A

DOI: 10.17235/reed.2021.8372/2021

Letter

Endoscopic full-thickness resection of a gastric schwannoma

DOI: 10.17235/reed.2021.8385/2021

Digestive Diseases Image

Giant cystic hepatocarcinoma in the absence of cirrhosis

DOI: 10.17235/reed.2021.8313/2021

Digestive Diseases Image

Bezoar: an uncommon cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2021.8311/2021

Digestive Diseases Image

Kaposi’s sarcoma with atypical gastrointestinal involvement

DOI: 10.17235/reed.2021.8275/2021

Letter

COVID-19 and aorto-enteric fistula

DOI: 10.17235/reed.2021.8272/2021

Digestive Diseases Image

A case of duodenal-type follicular lymphoma

DOI: 10.17235/reed.2021.8233/2021

Letter

Unexpected diagnosis for nodular hepatic lesions

DOI: 10.17235/reed.2021.8230/2021

Digestive Diseases Image

Imaging findings of melanoma metastasis in the gallbladder

DOI: 10.17235/reed.2021.8176/2021

Letter

Clip migration after cholecystectomy

DOI: 10.17235/reed.2021.8156/2021

Digestive Diseases Image

Ink stained gastric lesions: a rare cause of gastrointestinal bleeding

DOI: 10.17235/reed.2021.8141/2021

Digestive Diseases Image

Gastric ischemia: cross-sectional imaging findings via a case series

DOI: 10.17235/reed.2021.8142/2021

Digestive Diseases Image

Portal thrombosis in a patient with SARS-CoV-2 infection

DOI: 10.17235/reed.2021.8099/2021

Letter

EBVMCU in a liver-transplant patient

DOI: 10.17235/reed.2021.8064/2021

Digestive Diseases Image

Abdominal cocoon sign: an unusual cause of intestinal obstruction

DOI: 10.17235/reed.2021.8057/2021

Letter

Autoimmune hepatitis triggered by COVID-19

DOI: 10.17235/reed.2021.8045/2021

Review

A review of the diagnosis and management of liver hydatid cyst

DOI: 10.17235/reed.2021.7896/2021

Letter

Pneumoperitoneum and COVID-19. A causal association?

DOI: 10.17235/reed.2021.7877/2021

Digestive Diseases Image

Dubin-Johnson syndrome as a laparoscopic finding

DOI: 10.17235/reed.2021.7866/2021

Letter

COVID-19 and the liver: the chicken or the egg dilemma

DOI: 10.17235/reed.2021.7861/2021

Letter

Acute pancreatitis related to SARS-CoV-2 infection. Disclaimer

DOI: 10.17235/reed.2021.7853/2021

Digestive Diseases Image

Gastric plasmacytoma: a rare cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2021.7816/2021

Letter

Pancreatic injury and acute pancreatitis in COVID-19 patients

DOI: 10.17235/reed.2021.7807/2021

Letter

Bochdalek hernia: use of capsule endoscopy

DOI: 10.17235/reed.2021.7760/2020

Letter

Radical surgery for liver hydatidosis

DOI: 10.17235/reed.2021.7743/2020

Digestive Diseases Image

Percutaneous treatment of a splenorenal shunt with an atrial septal closure device

DOI: 10.17235/reed.2020.7701/2020

Editorial

Leading in turbulent times with the aim to serve

DOI: 10.17235/reed.2020.7684/2020

Letter

Ischemic gastritis and severe diabetic ketoacidosis

DOI: 10.17235/reed.2020.7655/2020

Digestive Diseases Image

Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the liver

DOI: 10.17235/reed.2020.7602/2020

Letter

Pancreatic injury in COVID-19: pathogenesis and challenges

DOI: 10.17235/reed.2020.7541/2020

Letter

Gastric caustic injury after organophosphate poisoning

DOI: 10.17235/reed.2020.7540/2020

Letter

SARS-CoV-2 and acute pancreatitis: a new etiological agent?

DOI: 10.17235/reed.2020.7481/2020

Review

Physical frailty in liver transplantation

DOI: 10.17235/reed.2020.7448/2020

Letter

Latin American authorship in scientific production on COVID-19

DOI: 10.17235/reed.2020.7432/2020

Letter

Basic training in gastrointestinal endoscopy: recording images

DOI: 10.17235/reed.2020.7385/2020

Letter

COVID-19. Immunothrombosis and the gastrointestinal tract

DOI: 10.17235/reed.2020.7292/2020

Letter

Acute hepatitis due to olmesartan: an uncommon entity

DOI: 10.17235/reed.2020.7236/2020

Letter

Acute gastric dilatation in a patient with anorexia nervosa

DOI: 10.17235/reed.2020.7235/2020

Letter

Management of hepatic artery aneurysms

DOI: 10.17235/reed.2020.7219/2020

Letter

The effect of Adacolumn® on ulcerative colitis with COVID-19

DOI: 10.17235/reed.2020.7156/2020

Rapid reviews

COVID-19, coronavirus, SARS-CoV-2 and the small bowel

DOI: 10.17235/reed.2020.7137/2020

Digestive Diseases Image

Epithelioid hemangioendothelioma: a rare cause of a liver tumor

DOI: 10.17235/reed.2020.7127/2020

Letter

Chronic intestinal pseudo-obstruction in MELAS

DOI: 10.17235/reed.2020.7099/2020

Original

Gastric plexiform fibromyxoma, an uncommon mesenchymal tumor

DOI: 10.17235/reed.2020.7048/2020

Letter

Development of Barrett’s esophagus after a total gastrectomy

DOI: 10.17235/reed.2020.7041/2020

Review

Pyroptosis in liver disease

DOI: 10.17235/reed.2020.7034/2020

Letter

Biopsy for hepatocellular carcinoma: only occasionally

DOI: 10.17235/reed.2020.6935/2020

Letter

Secondary gastric lymphoma - Do we know its endoscopic findings?

DOI: 10.17235/reed.2020.6868/2020

Letter

Luetic gastritis: an uncommon cause of gastritis

DOI: 10.17235/reed.2020.6870/2020

Letter

Digestive involvement in a patient with Lambert-Eaton syndrome

DOI: 10.17235/reed.2020.6846/2019

Digestive Diseases Image

Groove pancreatitis: a rare cause of severe gastric dilation

DOI: 10.17235/reed.2020.6765/2019

Editorial

Small but great steps

DOI: 10.17235/reed.2019.6758/2019

Letter

Gastric ulcer due to mucormycosis in a critical patient

DOI: 10.17235/reed.2020.6636/2019

Letter

An atypical bronchogenic cyst with yeast over-infection

DOI: 10.17235/reed.2020.6560/2019

Original

A new pattern in hepatitis A virus infection in an urban population

DOI: 10.17235/reed.2020.6526/2019

Letter

Misplacement of a nasogastric feeding tube: a case report

DOI: 10.17235/reed.2020.6512/2019

Letter

Primary gastric choriocarcinoma

DOI: 10.17235/reed.2020.6478/2019

Digestive Diseases Image

Metastatic melanoma of the gallbladder: an uncommon finding

DOI: 10.17235/reed.2020.6407/2019

Letter

Ischemic gastritis due to oral iron

DOI: 10.17235/reed.2019.6401/2019

Case Report

Ectopic hepatocellular carcinoma arising from the peritoneum

DOI: 10.17235/reed.2019.6408/2019

Letter

Hepatic epithelioid angiomyolipoma: contribution of a new case

DOI: 10.17235/reed.2019.6388/2019

Digestive Diseases Image

Concurrent hepatic and renal angiomyolipomas in tuberous sclerosis complex

DOI: 10.17235/reed.2020.6376/2019

Letter

Twisting of sleeve gastrectomy: two ways of clinic presentation

DOI: 10.17235/reed.2019.6366/2019

Digestive Diseases Image

An unusual endoscopic presentation of diffuse duodenal gastric heterotopia

DOI: 10.17235/reed.2020.6372/2019

Original

Quality of life study in asymptomatic patients with hepatitis C

DOI: 10.17235/reed.2019.6339/2019

Case Report

Emphysematous esophagitis with gastric perforation

DOI: 10.17235/reed.2019.6322/2019

Review

Psoriasis and fatty liver: a harmful synergy

DOI: 10.17235/reed.2019.6263/2019

Letter

Endoscopically diagnosed systemic mastocytosis

DOI: 10.17235/reed.2019.6246/2019

Digestive Diseases Image

Cervical arthrodesis penetrated into the esophagus detected by gastroscopy

DOI: 10.17235/reed.2019.6222/2019

Special Article

The quality of abdominal ultrasound: a much-needed consensus

DOI: 10.17235/reed.2019.6177/2019

Letter

Gastric serrated adenoma

DOI: 10.17235/reed.2019.6145/2018

Letter

A giant liver abscess due to Fasciola hepatica infection

DOI: 10.17235/reed.2019.6136/2018

Digestive Diseases Image

A rare heterotopic gastric mucosa appearing between the muscularis mucosae and submucosa

DOI: 10.17235/reed.2019.6134/2018

Special Article

Quality indicators in gastroscopy. Gastroscopy procedure

DOI: 10.17235/reed.2019.6023/2018

Special Article

Consensus document on exclusion diets in irritable bowel syndrome (IBS)

DOI: 10.17235/reed.2018.5941/2018

Digestive Diseases Image

Secondary gastroduodenal plasmacytoma in a patient with multiple myeloma

DOI: 10.17235/reed.2019.5923/2018

Letter

Sometimes things are what they seem

DOI: 10.17235/reed.2019.5911/2018

Letter

Primary squamous cell carcinoma of the stomach: a rare entity

DOI: 10.17235/reed.2018.5900/2018

Editorial

Lung transplantation and esophageal dysfunction

DOI: 10.17235/reed.2018.5693/2018

Digestive Diseases Image

String sign of Kantor in a patient with Crohn’s disease

DOI: 10.17235/reed.2018.5598/2018

Digestive Diseases Image

Painless jaundice as an initial presentation of lung adenocarcinoma

DOI: 10.17235/reed.2018.5587/2018

Letter

An esophageal cyst containing heterotopic gastric glands

DOI: 10.17235/reed.2018.5530/2018

Digestive Diseases Image

Dysphagia and hematemesis caused by an intramural esophageal dissection

DOI: 10.17235/reed.2018.5471/2018

Editorial

On the centenary of The Spanish Journal of Gastroenterology (REED)

DOI: 10.17235/reed.2017.5427/2017

Letter

Giant hepatobiliary cystadenoma: clinic-pathological findings

DOI: 10.17235/reed.2018.5414/2017

Letter to the Editor

Post-transplant lymphoproliferative disease after liver transplantation

DOI: 10.17235/reed.2017.5387/2017

Letter to the Editor

EUS-guided ethanol ablation therapy for gastric stromal tumors

DOI: 10.17235/reed.2017.5361/2017

Letter to the Editor

Complicated peribiliary cysts in patient without any prior liver disease

DOI: 10.17235/reed.2017.5350/2017

Letter to the Editor

Inverted Meckel’s diverticulum in an adult patient diagnosed via capsule endoscopy

DOI: 10.17235/reed.2018.5347/2017

Letter to the Editor

Severe obscure gastrointestinal bleeding successfully treated with idarucizumab

DOI: 10.17235/reed.2018.5298/2017

Letter to the Editor

GETTEMO position statement on bariatric endoscopic techniques as a voluntary medicine

DOI: 10.17235/reed.2017.5144/2017

Letter to the Editor

A patient with Castleman’s disease mimicking acute pancreatitis

DOI: 10.17235/reed.2017.5120/2017

Letter to the Editor

Acute gastric dilatation after dietary violation

DOI: 10.17235/reed.2017.5111/2017

Original

Gastroenterology - Evolution of specialty choice in recent years

DOI: 10.17235/reed.2017.4977/2017

Digestive Diseases Image

Metastasis of dermatofibrosarcoma diagnosed by capsule endoscopy

DOI: 10.17235/reed.2018.4900/2017

Letter to the Editor

Chronic diarrhea, weight loss and heart failure. Features of the same disease?

DOI: 10.17235/reed.2017.4874/2017

Letter to the Editor

A rare cause of intestinal bleeding: duodenal metastasis from endometrial cancer

DOI: 10.17235/reed.2017.4822/2017

Letter to the Editor

Gangliocytic paraganglioma: an unusual cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2017.4808/2016

Letter to the Editor

Pancreatic neuroendocrine tumors

DOI: 10.17235/reed.2017.4725/2016

Original

Usefulness of an intra-gastric balloon before bariatric surgery

DOI: 10.17235/reed.2017.4624/2016

Digestive Diseases Image

Debut of an unusual liver cirrhosis

Letter to the Editor

Giant esophageal diverticulum as a new clinical indication for endoscopic gastrostomy

DOI: 10.17235/reed.2017.4528/2016

Letter to the Editor

Liver metastasis from colorectal cancer 12 years after liver transplantation

DOI: 10.17235/reed.2017.4507/2016

Letter to the Editor

Intramural gastric hematoma in the context of an acute pancreatitis

DOI: 10.17235/reed.2017.4494/2016

Letter to the Editor

Sister Mary Joseph’s nodule as initial pancreatic cancer manifestation

DOI: 10.17235/reed.2016.4479/2016

Letter to the Editor

Alopecia areata as a paraneoplastic syndrome of gastric cancer

DOI: 10.17235/reed.2016.4455/2016

Original

Practical aspects of high resolution esophageal manometry

DOI: 10.17235/reed.2016.4441/2016

Letter to the Editor

Management of non-surgical pneumoperitoneum

DOI: 10.17235/reed.2016.4215/2016

Case Report

The clinical extremes of autoimmune cholangitis

DOI: 10.17235/reed.2017.4167/2015

Review

Serrated lesions and serrated polyposis syndrome

DOI: 10.17235/reed.2017.4065/2015

Letter to the Editor

Lupus as a paraneoplastic manifestation of cholangiocarcinoma

DOI: 10.17235/reed.2016.4064/2015

Letter to the Editor

Endobronchial metastases of colorectal cancer

DOI: 10.17235/reed.2016.4080/2015

Letter to the Editor

Acute transverse colon volvulus with secondary gastric isquemia. Case report

DOI: 10.17235/reed.2016.4024/2015

Letter to the Editor

Hiatal herniation following total gastrectomy

DOI: 10.17235/reed.2016.4009/2015

Letter to the Editor

Gastric neuroendocrine tumor presenting with gastrointestinal bleeding

DOI: 10.17235/reed.2015.3998/2015

Letter to the Editor

Endoscopic submucosal dissection for a gastric fibrolipoma

DOI: 10.17235/reed.2015.3982/2015

Case Report

Metastatic Crohn’s disease in pediatrics

DOI: 10.17235/reed.2016.3948/2015

Letter to the Editor

Authors' reply: Spanish or English in scientific reporting

DOI: 10.17235/reed.2015.3945/2015

Case Report

Glycogenic hepatopathy in young adults: a case series

DOI: 10.17235/reed.2016.3934/2015

Case Report

Primary esophageal melanoma: report of a case

DOI: 10.17235/reed.2016.3908/2015

Case Report

Gastric varicella: two cases in cancer patients

DOI: 10.17235/reed.2016.3925/2015

Letter to the Editor

Case report: Amyand’s hernia, diagnosis to consider in a routine procedure

DOI: 10.17235/reed.2015.3816/2015

Review

Impaired esophageal motor function in eosinophilic esophagitis

DOI: 10.17235/reed.2015.3801/2015

Case Report

Appendicular bleeding: an excepcional cause of lower hemorrhage

DOI: 10.17235/reed.2015.3828/2015

Digestive Diseases Image

Granular cell tumor of cecum

Review

Anal Intraepithelial neoplasia: A narrative review

DOI: 10.17235/reed.2015.3788/2015

Case Report

Pelvic inflammatory myofibroblastic tumor mimicking a rectal cancer

DOI: 10.17235/reed.2015.3777/2015

Case Report

Downhill varices: an uncommon cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2015.3697/2015

Letter to the Editor

Acute gastric dilatation in the context of bulimia nervosa

DOI: 10.17235/reed.2015.3673/2015

Letter to the Editor

Duodenal involvement by seminomatous tumors

DOI: 10.17235/reed.2015.3646/2014

Letter to the Editor

Synchronic gastric and pancreatic ductal adenocarcinoma. A case report

DOI: 10.17235/reed.2015.3720/2014

Letter to the Editor

Severe acute liver failure and thyrotoxicosis: an unusual association

DOI: 10.17235/reed.2015.3607/2014

Letter to the Editor

Leiomyosarcoma of the ascending colon: a rare tumor with poor prognosis

DOI: 10.17235/reed.2015.3606/2014

Letter to the Editor

PITAVASTATIN: OTHER STATIN TO BE USED AND MONITORED

DOI: 10.17235/reed.2015.3565/2014

Letter to the Editor

Liver abscess by Eikenella Corrodens

DOI: 10.17235/reed.2015.3613/2014

Letter to the Editor

Leiomyoma of the round ligament of the liver: Report of one case

DOI: 10.17235/reed.2015.3725/2014

Citation tools
Ampuero J, Sánchez Y, García-Lozano M, Maya-Miles D, Romero Gómez M. Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis. 7397/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1955 visits.
This article has been downloaded 368 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 08/07/2020

Accepted: 24/09/2020

Online First: 03/12/2020

Published: 08/02/2021

Article revision time: 72 days

Article Online First time: 148 days

Article editing time: 215 days


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology