Year 2023 / Volume 115 / Number 11
Letter
Gastric mixed neuroendocrine/non neuroendocrine neoplasia: a rare entity

670-671

DOI: 10.17235/reed.2023.9988/2023

José Damasceno e Costa, Rita Seara Costa, Hélder Deveza Moreira, Aníbal Ferreira,

Abstract
Gastric neoplasms have different histological subtypes. Mixed neuroendocrine/non neuroendocrine neoplasms (MiNEN), as defined by the World Health Organization (WHO) 2019 Classification of Tumours of the Digestive System, are rare composite tumours bearing morphological characteristics of more than one histological type. Historically, the diagnosis requires that each component accounts for at least 30% of the total tumour burden. We present the case of a 70-year-old male, who was referred to our endoscopy unit for resection of a depressed lesion (Paris classification type 0 IIc) of 40mm in largest diameter, located on the lesser curvature of the gastric body. The lesion was submitted to en bloc resection by endoscopic submucosal dissection. Histological examination revealed a poorly differentiated intramucosal adenocarcinoma and a grade G3 well differentiated neuroendocrine tumour (NET), on a background of chronic atrophic gastritis. Unfortunately, examination of the NET component revealed intercepted margins. The patient is currently undergoing tumour staging and will be discussed by a multidisciplinary team to determine subsequent management.
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References
1. Elpek GO. Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update. World J Gastroenterol. 2022 Feb 28;28(8):794–810.
2. Nagtegaal ID, Odze RD, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020 Jan;76(2):182–8.
3. Arencibia Pérez B, Delgado Sánchez JJ, Marchena Gómez J. Mixed adenoneuroendocrine carcinoma of the colon - a complex and unique clinical duality. Rev Esp Enferm Dig. 2021 Nov;113(11):796-797.
4. Wang Q, Li L, Li J, et al. Mixed adenoneuroendocrine carcinoma of the gallbladder. Rev Esp Enferm Dig. 2023 Apr 19;116.
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Costa J, Costa R, Moreira H, Ferreira A. Gastric mixed neuroendocrine/non neuroendocrine neoplasia: a rare entity. 9988/2023


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Publication history

Received: 28/09/2023

Accepted: 29/09/2023

Online First: 26/10/2023

Published: 13/11/2023

Article Online First time: 28 days

Article editing time: 46 days


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