Year 2024 / Volume 116 / Number 8
Letter
Clinicopathological characteristics of well-differentiated gastric cancer missed by endoscopy

452-453

DOI: 10.17235/reed.2023.9980/2023

Ruixue Lei, Haijun Yang,

Abstract
The objective was to explore the clinicopathological features of moderately well-differentiated gastric cancer missed by endoscopy. The clinicopathological data of 88 patients who were diagnosed as moderately well-differentiated gastric cancer by biopsy and pathology from January 2019 to December 2020 in Anyang Tumor Hospital were analyzed retrospectively. The clinicopathological features and immunophenotypic characteristics of these gastric cancers were analyzed together with the literature review. Seventy males and 18 females were included in this study. There were 59 cases of gastritis, 14 cases of ulcer and 15 cases of polyp under endoscope. Based on mucous phenotype, there were 27 gastric cases, 18 intestinal cases, 39 gastrointestinal cases and 4 untyping cases. 54 cases expressed mutant p53 and 34 cases had wild type p53. None of the indicators could yield reliablediagnosis, which requires comprehensive morphological and immunohistochemical analysis by the pathologist. Meanwhile, the clinician should give the patient a systematic treatment plan incuding endoscopy, magnifying endoscopy, NBI, linear endoscopic ultrasound and other examinations. Regardless of the diagnostic criteria, once the pathology suggests a tumor lesion, local resection should be performed first. Additional surgery can be performed if there is submucosal invasion.
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References
[1] Kim MJ, Hong JH, Park ES, et al. Gastric metastasisfrom primary lung adenocarcinoma mimickingprimarygastric cancer[J]. World J Gastrointest Oncol,2015,7(3):12-16.
[2] KASUGAI T: Prognosis of early gastric cancer. Gastroenterology 58:429, 1970.
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[4]Piao Z, Ding X, Jiang H, et al. Pathological diagnosis of gastric adenoma and early well-differentiated adenocarcinoma in Japan. Chinese Journal of Digestive Endoscopy, 2020,37:11-14.
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Lei R, Yang H. Clinicopathological characteristics of well-differentiated gastric cancer missed by endoscopy. 9980/2023


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Publication history

Received: 24/09/2023

Accepted: 29/09/2023

Online First: 26/10/2023

Published: 01/08/2024

Article Online First time: 32 days

Article editing time: 312 days


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