Year 2025 / Volume 117 / Number 2
Letter
A rare case of hepatoid gastric adenocarcinoma

112-113

DOI: 10.17235/reed.2024.10285/2024

Elena Pablo-Martín, Laura Corvo-Félix, Jonnathan Roldán Ruiz, Juan Carlos Redondo González, Lourdes Cuesta Martínez, Pablo Reguera Puertas, Luis Figuero-Pérez, Emilio Fonseca-Sánchez,

Abstract
Hepatoid gastric adenocarcinoma (HGA) is a rare subtype of gastric cancer. It usually presents with non-specific digestive tract symptoms and is usually diagnosed in advanced stages. It has radiological and histological similarities to hepatocarcinoma (HCC), and serum elevation of alpha-fetoprotein (AFP) is characteristic, as is positive staining for this marker on immunohistochemistry. Given the low incidence and poor prognosis of this type of tumour, it is essential to make a correct differential diagnosis and to initiate early surgical treatment in localised stages and systemic treatment in those where the disease is disseminated. In this context, we present the case of a GHA diagnosed this year in our centre.
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References
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4. Zhao M, Sun L, Lai JZ, Shi H, Mei K, et al. Expression of RNA-binding protein LIN28 in classic gastric hepatoid carcinomas, gastric fetal type gastrointestinal adenocarcinomas, and hepatocellular carcinomas: an immunohistochemical study with comparison to SALL4, Alpha-fetoprotein, glypican-3, and Hep Par1. Pathol Res Pract. 2018; 214: 1707-12.
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Citation tools
Pablo-Martín E, Corvo-Félix L, Roldán Ruiz J, Redondo González J, Cuesta Martínez L, Reguera Puertas P, et all. A rare case of hepatoid gastric adenocarcinoma. 10285/2024


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Publication history

Received: 18/01/2024

Accepted: 29/01/2024

Online First: 02/02/2024

Published: 05/02/2025

Article Online First time: 15 days

Article editing time: 384 days


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