Year 2024 / Volume 116 / Number 1
Original
Age, period and cohort effects on gastric cancer mortality in Spain, 1980-2021

22-28

DOI: 10.17235/reed.2023.9668/2023

Lucía Cayuela, Álvaro Giráldez Gallego, Marta Garzón Benavides, José Manuel Sousa Martín, Aurelio Cayuela,

Abstract
Background: this study aimed to evaluate the effects of age, time period and cohort (A-P-C) on gastric cancer (GC) mortality in Spain from 1980 to 2021. Methods: an ecological trend study was performed (with aggregated data obtained from the Spanish National Statistics Institute (INE). Joinpoint regression software was used to estimate rates by sex and age group (< 35, 35-64, > 64 years) and mortality trends. The National Cancer Institute A-P-C tools were used to assess the effects of age, time of death and birth cohort. Results: GC mortality rates in Spain decreased significantly in both sexes. In the under-35 age group, rates were stable after an initial significant decline. In the 35-64 age group, the decline was more pronounced in males than in females. In the 65+ age group, rates fell significantly for both sexes, but more so for females than for males. The net drift and local drift also showed significant decreases across all age groups from 24 years onwards. GC mortality rates increased with age and decreased with calendar time and successive birth cohorts, regardless of sex. The ratio of age-specific rates between males and females increased with age, and birth cohort relative risk estimates followed a steady downward trend until the mid-1970s, after which the decline stabilized. The relative risk decreased for both sexes, with a more pronounced decrease in males. Conclusion: GC mortality rates in Spain have been decreasing over time and across successive birth cohorts, with a stabilizing trend observed for those under 35 years of age.
Lay Summary
This study aimed to examine how different factors such as age, period, and cohort (A-P-C) affect mortality from gastric cancer (GC) in Spain over a 41-year period from 1980 to 2021. The study analyzed aggregated data obtained from the National Institute of Statistics, and used statistical methods such as joinpoint regression software and National Cancer Institute A-P-C tools to estimate mortality rates and trends by sex and age group. The study found that overall GC mortality rates decreased significantly for both sexes in Spain during the study period. However, there were some variations in the trends by age group and sex. In the under-35 age group, rates were stable after an initial significant decline. In the 35-64 age group, the decline was more pronounced in men than in women. In the 65+ age group, rates fell significantly for both sexes, but more so for women than for men. The study also found that GC mortality rates increased with age, and decreased with calendar time and successive birth cohorts, regardless of sex. The ratio of age-specific rates between men and women increased with age, and birth cohort relative risk estimates followed a steady downward trend until the mid-1970s, after which the decline stabilized. The relative risk decreased for both sexes, with a more pronounced decrease in men. Overall, the study provides important insights into the trends and factors that affect mortality from GC in Spain. The findings suggest that efforts to reduce GC mortality should focus on early detection and prevention strategies, particularly for those at higher risk due to age and sex.
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Cayuela L, Giráldez Gallego Á, Garzón Benavides M, Sousa Martín J, Cayuela A. Age, period and cohort effects on gastric cancer mortality in Spain, 1980-2021. 9668/2023


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Publication history

Received: 15/04/2023

Accepted: 27/07/2023

Online First: 04/08/2023

Published: 11/01/2024

Article revision time: 99 days

Article Online First time: 111 days

Article editing time: 271 days


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