Year 2021 / Volume 113 / Number 2
Original
Liver manifestations in COVID-19 and the influence of pre-existing liver disease in the course of the infection

103-109

DOI: 10.17235/reed.2020.7627/2020

María Fernanda Guerra Veloz, Patricia Cordero Ruiz, María José Ríos-Villegas, Pilar Del Pino Bellido, José Bravo-Ferrer, Rocío Galvés Cordero, María Lorena Cadena Herrera, Carmen Vías Parrado, Francisco Bellido Muñoz, Francisco Vega Rodríguez, Ángel Caunedo Álvarez, Jesús Rodríguez-Baño, Isabel Carmona Soria,

Abstract
Introduction: patients with advanced chronic liver disease (CLD) may be at an increased risk of a severe course due to cirrhosis-associated immune dysfunction. The aim of this study was to determine the prevalence of CLD in COVID-19 patients and to analyze the course of the infection, compared with patients with non-liver disease. Materials and methods: this was a retrospective single center study of all patients with a positive SARS-CoV-2 polymerase chain reaction (PCR) test from March 23rd to April 30th, 2020. Clinical and biochemical data of patients with and without CLD and COVID-19 were collected from the medical records. Result: four hundred and forty-seven patients with a SARS-CoV-2 positive PCR were included, 6.3 % had CLD; 69.7 % of patients with CLD were male, with a median age of 65.5 years and active alcohol consumption and smoking; 75 % had non-advanced liver fibrosis and most had non-alcoholic fatty liver disease (NAFLD). The hospital admission rate (92.9 % vs 47.7 %, p < 0.001), concomitant comorbidities (diabetes 38.5 vs 16.5 %, p = 0.011; obesity 30.8 vs 8.5 %, p = 0.033; cancer 23.1 vs 5 %, p = 0.027; and chronic obstructive pulmonary disease (COPD) 19.2 vs 9 %, p = 0.009) and concomitant antibiotics treatment (19.3 vs 5 %, p = 0.018) were higher in patients with CLD than in those without CLD. In-patient hospital mortality rates were similar in both groups (30.8 vs 19.6 %, p = 0.289). The presence of CLD was not associated with mortality (OR = 1.06; 95 % CI = 0.35-3.18; p = 0.924). However, patients with CLD and COVID-19 who were male, obese or under concomitant antibiotic treatment had the highest risk of mortality according to the univariate analysis. Conclusion: patients with CLD had a higher risk of hospital admission, with worse outcomes during the COVID-19 infection associated to other concomitant comorbidities and a suspicion of bacterial co-infection.
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Guerra Veloz M, Cordero Ruiz P, Ríos-Villegas M, Del Pino Bellido P, Bravo-Ferrer J, Galvés Cordero R, et all. Liver manifestations in COVID-19 and the influence of pre-existing liver disease in the course of the infection . 7627/2020


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Publication history

Received: 02/11/2020

Accepted: 11/12/2020

Online First: 04/01/2021

Published: 08/02/2021

Article revision time: 23 days

Article Online First time: 63 days

Article editing time: 98 days


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