Year 2021 / Volume 113 / Number 7
Original
High expression of NDRG3 correlates with poor prognosis in gastric cancer patients

524-528

DOI: 10.17235/reed.2021.7723/2020

Yun Liu, Jinxuan Xia, Yong Zhou, Shihe Shao,

Abstract
Introduction: N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague. Material and methods: Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection. Results: NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival. Discussion: thus, NDRG3 may be a novel predictor of GC prognosis.
Share Button
New comment
Comments
No comments for this article
References
[1]Fang J, Wang H, Liu Y, et al. High KRT8 expression promotes tumor progression and metastasis of gastric cancer. Cancer Sci 2017;108(2):178–86.
[2]Liu Y, Shao C, Zhu LQ, et, al. High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer. Dig Dis Sci 2018;63(9):2294-00.
[3] Karimi P, Islami F, Anandasabapathy S, et al. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev 2014;23(5):700–13.
[4] Yoon H, Kim N. Diagnosis and management of high risk group for gastric cancer. Gut Liver 2015;9(1):5–17.
[5] Wang F, Meng W, Wang B, et al. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett 2014;10;345(2):196-202.
[6] Shimizu T, Marusawa H, Watanabe N, et al. Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer. Gastroenterol Clin North Am 2015;44(3):625-38.
[7] Guggenheim DE, Shah MA. Gastric cancer epidemiology and risk factors. J Surg Oncol. 2013;107(3):230-6.
[8] Johnston FM, Beckman M. Updates on Management of Gastric Cancer. Curr Oncol Rep. 2019;21(8):67.
[9] Yu J, Shen J, Qiao X, et al. The SNHG20 / miR-140-5p / NDRG3 axis contributes to resistance to 5-fluorouracil in gastric cancer. Oncol Lett 2019; 18 (2): 1337-43.
[10] Yu C, Hao X, Zhang S, et al. Characterization of the prognostic values of the NDRG family in gastric cancer. Therapeutic advances in gastroenterology. January 2019.
[11] Kim MC, Park MH, Kang SH, et al. NDRG3 protein expression is associated with aggressive biologic phenotype and unfavorable outcome in patients with invasive breast cancer. Int J Clin Exp Pathol. 2019 ;12(10):3886-93.
[12] Estiar MA, Zare AA, Esmaeili R, et al. Clinical significance of NDRG3 in patients with breast cancer. Future Oncol. 2017;13(11):961-9.
[13] Jing JS, Li H, Wang SC, et al. NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma. Biosci Rep. 2018;38(6):BSR20180907.
[14] Okuda T, Kondoh H. Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun 1999;266(1): 208-15.
Related articles

Original

Can we optimize CEA as a response marker in rectal cancer?

DOI: 10.17235/reed.2020.7321/2020

Letter

Primary squamous cell carcinoma of the stomach: a rare entity

DOI: 10.17235/reed.2018.5900/2018

Editorial

The right colon challenge

DOI: 10.17235/reed.2018.5544/2018

Letter to the Editor

Neuroendocrine tumors of the pancreas: keys issues in dealing with heterogeneity

DOI: 10.17235/reed.2017.4997/2017

Letter to the Editor

Pancreatic neuroendocrine tumors. Prognostic factors

DOI: 10.17235/reed.2017.5109/2017

Editorial

Pancreas neuroendocrine tumors - not so rare or benign

DOI: 10.17235/reed.2016.4672/2016

Letter to the Editor

Alopecia areata as a paraneoplastic syndrome of gastric cancer

DOI: 10.17235/reed.2016.4455/2016

Citation tools
Liu Y, Xia J, Zhou Y, Shao S. High expression of NDRG3 correlates with poor prognosis in gastric cancer patients . 7723/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1131 visits.
This article has been downloaded 116 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 12/12/2020

Accepted: 27/01/2021

Online First: 10/02/2021

Published: 07/07/2021

Article revision time: 42 days

Article Online First time: 60 days

Article editing time: 207 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology