Year 2021 / Volume 113 / Number 7
Original
High expression of NDRG3 correlates with poor prognosis in gastric cancer patients

524-528

DOI: 10.17235/reed.2021.7723/2020

Yun Liu, Jinxuan Xia, Yong Zhou, Shihe Shao,

Abstract
Introduction: N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague. Material and methods: Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection. Results: NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival. Discussion: thus, NDRG3 may be a novel predictor of GC prognosis.
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References
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Liu Y, Xia J, Zhou Y, Shao S. High expression of NDRG3 correlates with poor prognosis in gastric cancer patients . 7723/2020


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Publication history

Received: 12/12/2020

Accepted: 27/01/2021

Online First: 10/02/2021

Published: 07/07/2021

Article revision time: 42 days

Article Online First time: 60 days

Article editing time: 207 days


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