Year 2019 / Volume 111 / Number 7
Original
Prognostic influence of CDX2 expression in gastric carcinoma after surgery with a curative intent

514-518

DOI: 10.17235/reed.2019.5976/2018

Lourdes Estrada Muñoz, Soledad García Gómez de las Heras, Cristina Díaz del Arco, María Angeles Cerón Nieto, Jesús Chicharro Uriguen, María Jesús Fernández Aceñero,

Abstract
Introduction and objectives: CDX2 is a specific transcription factor with a significant role in the early differentiation and maintenance of intestinal epithelial cells during gastrointestinal development and also as a tumor suppressor. The aim of this study was to assess the potential role of CDX2 expression as a prognostic predictor. Material and methods: ninety-two of 206 (44.6%) patients with gastric carcinoma that underwent a curative surgery and had immunohistochemical staining for CDX2 were enrolled into the study; 51.1% were female and the average age was 74.07 years. Overall, 56.5% of tumors were of the intestinal type, 33.7% were diffuse and 9.8% were mixed; 23.9% were T1/T2, 76.1% were T3/T4 and lymph node metastases (N+) were identified in 69.6% of cases; 13% (12) were clinical stage I, 40.2% (37) were stage II and 46.7% (43) were stage III. Results: a total of 68.5% (63) expressed CDX2. Our study suggests that CDX2 expression (HR = 0.339, p = 0.024) represents an independent risk marker together with the Lauren type (HR = 3.471, p = 0.022). There was association between a milder clinical stage and CDX2 expression (stage I) (p = 0.046). A significant difference was found in overall survival that favored patients with positive CDX2 expression (85.7% vs 65.5%, p = 0.012). Conclusion: our results confirm that CDX2 expression in gastric carcinoma is associated with improved prognosis, although further studies are needed to draw definitive conclusions.
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Estrada Muñoz L, García Gómez de las Heras S, Díaz del Arco C, Cerón Nieto M, Chicharro Uriguen J, Fernández Aceñero M, et all. Prognostic influence of CDX2 expression in gastric carcinoma after surgery with a curative intent. 5976/2018


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Publication history

Received: 14/10/2018

Accepted: 21/12/2018

Online First: 29/05/2019

Published: 04/07/2019

Article revision time: 56 days

Article Online First time: 227 days

Article editing time: 263 days


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