Year 2019 / Volume 111 / Number 12
Original
Elevated serum levels of interleukin-37 correlate with poor prognosis in gastric cancer

941-945

DOI: 10.17235/reed.2019.6460/2019

Yan Zhang, Min Tang, Xiao-Ge Wang, Jin-Hua Gu, Li-Na Zhou, Jun Jin, Ping Li, Li-Qiang Wang, Min-Bin Chen,

Abstract
Background: interleukin-37 (IL-37) is as a natural suppressor of the innate inflammatory and immune responses. It has also been reported to be involved in carcinogenesis and metastasis. The present case-control study was designed to investigate the role of serum levels of IL-37 in patients with gastric cancer. Methods: serum IL-37 levels were determined using the enzyme-linked immunosorbent assay in 180 patients diagnosed with gastric cancer and 100 healthy controls. The association between IL-37 levels and clinical factors was assessed. Univariate and multivariate analyses were performed to investigate the prognostic significance of these parameters in gastric cancer. Results: serum IL-37 levels in gastric cancer patients (5.606 ± 0.837 pg/ml) were significantly higher than those in healthy controls (2.364 ± 0.210 pg/ml, p < 0.001). High serum IL-37 levels were related to a poorly differentiated histologic type (p = 0.046) and advanced T stage (p = 0.003). The Kaplan-Meier survival analysis indicated that the high-IL-37 group had a poorer overall survival and progression-free survival (overall survival [OS]: 39.0 months vs 13.0 months, p < 0.001, progression-free survival [PFS]: 25.0 months vs 10.0 months, p < 0.001). Multivariate analyses showed serum IL-37 to be an independent prognostic factor for gastric cancer patients (OS: hazard ratios [HR] = 1.842, 95% CI: 1.190-2.854, p = 0.006; PFS: HR = 1.547, 95% CI: 1.014-2.359, p = 0.043). Conclusions: in conclusion, serum IL-37 levels were associated with poor overall survival and progression-free survival in gastric cancer patients. IL-37 may be a potential predictor of prognosis in gastric cancer.
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Zhang Y, Tang M, Wang X, Gu J, Zhou L, Jin J, et all. Elevated serum levels of interleukin-37 correlate with poor prognosis in gastric cancer. 6460/2019


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Publication history

Received: 22/06/2019

Accepted: 31/07/2019

Online First: 13/11/2019

Published: 05/12/2019

Article revision time: 33 days

Article Online First time: 144 days

Article editing time: 166 days


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