Year 2022 / Volume 114 / Number 12
Letter
Crohn’s disease induced by ocrelizumab in a patient with multiple sclerosis

766-767

DOI: 10.17235/reed.2022.9152/2022

Lorena Carballo-Folgoso, Miriam Celada-Sendino, Andrés Castaño-García, Pedro Oliva Nacarino, Patricia Morales del Burgo, Isabel Pérez-Martínez, Ruth de Francisco, Sabino Riestra,

Abstract
Drug-induced inflammatory bowel disease (IBD) is a clinical entity on the rise due to the frequent use of immunomodulatory therapy. Here we report the case of Crohn's disease due to Ocrelizumab, a humanized anti-CD20 monoclonal antibody approved for the treatment of multiple sclerosis. The exact mechanism by which anti-CD20 antibodies can trigger IBD is unknown, but since IBD and multiple sclerosis are processes included within the spectrum of immunomediated diseases, we could suggest that Ocrelizumab could trigger IBD in genetically predisposed patients.
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References
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2. Sunjaya DB, Taborda C, Obeng R, et al. First Case of Refractory Colitis Caused by Ocrelizumab. Inflamm Bowel Dis. 2020 May 12;26(6):e49.
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Citation tools
Carballo-Folgoso L, Celada-Sendino M, Castaño-García A, Oliva Nacarino P, Morales del Burgo P, Pérez-Martínez I, et all. Crohn’s disease induced by ocrelizumab in a patient with multiple sclerosis. 9152/2022


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Publication history

Received: 24/08/2022

Accepted: 30/08/2022

Online First: 30/09/2022

Published: 12/12/2022

Article Online First time: 37 days

Article editing time: 110 days


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