Year 2024 / Volume 116 / Number 9
Review
Clinical settings with tofacitinib in ulcerative colitis

484-492

DOI: 10.17235/reed.2022.8660/2022

Carlos Taxonera, Daniel Carpio López, Ana Cabez Manas, Joaquin Ernesto Hinojosa del Val,

Abstract
There are aspects of Janus kinase (JAK) inhibitors, specifically tofacitinib, that distinguish them from other drugs used in the treatment of ulcerative colitis (UC), such as their oral administration, their short half-life and their lack of immunogenicity. With the available evidence, we can highlight tofacitinib's quick action and flexibility of use, and its efficacy in patients, irrespective of whether or not they have previously been exposed to TNF inhibitors (anti-TNF drugs) and other biologic agents. Moreover, their safety profile is known and manageable, with certain considerations and precautions being factored in before and during treatment. In this review, we have defined various scenarios pertaining to this drug, e.g. its use in the event of failure or intolerance to previous treatment with biologics, when a quick response is required or in patients with other concurrent immune-mediated diseases.
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09/09/2024 18:35:40
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Taxonera C, Carpio López D, Cabez Manas A, Hinojosa del Val J. Clinical settings with tofacitinib in ulcerative colitis. 8660/2022


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Publication history

Received: 28/01/2022

Accepted: 10/03/2022

Online First: 04/04/2022

Published: 09/09/2024

Article revision time: 35 days

Article Online First time: 66 days

Article editing time: 955 days


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