Year 2023 / Volume 115 / Number 4
Letter
The neutrophil-lymphocyte ratio as a predictor of steroid response in patients with severe ulcerative colitis: a retrospective cohort study

197-199

DOI: 10.17235/reed.2022.9006/2022

Fernando Rubio-Acosta, Paulina Moctezuma-Velázquez, Emma Castro-Romero, Luis Uscanga-Domínguez, Kazuo Yamamoto-Furusho, Carlos Moctezuma-Velázquez,

Abstract
In this study we assessed the neutrophil-lymphocyte ratio (NLR) as a predictor of steroid non-response (SNR) in patients with acute severe ulcerative colitis and found a NLR on day 3 (NLR-3) >6.1 as a suitable cutoff point to identify SNR (OR 3.44, 95%CI 1.22-9.66) with sensitivity, specificity, positive predictive value, negative predictive value, and AUROC of 66.75, 63.2%, 35.9%, 86%, and 0.650, respectively. A model including bowel movements, albumin levels, and a NLR-3>6.1 had an AUC of 0.812 to predict SNR, with acceptable calibration.
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References
1 Okba, A., Amin, M. and Abdelmoaty, A., et al. Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity. Autoimmunity Highlights, 2019. 10(1).
2 Travis SP, Farrant JM, Ricketts C, et al. Predicting outcome in severe ulcerative colitis. Gut, 1996;38:905-910.
3 Moore, A. and Bressler, B. Acute Severe Ulcerative Colitis: The Oxford Criteria No Longer Predict In-Hospital Colectomy Rates. Digestive Diseases and Sciences, 2019. 65(2):576-580.
4 Akpinar MY, Ozin YO, Kaplan M, et al. Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio Predict Mucosal Disease Severity in Ulcerative Colitis. J Med Biochem. 2018;37(2):155–62.
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Citation tools
Rubio-Acosta F, Moctezuma-Velázquez P, Castro-Romero E, Uscanga-Domínguez L, Yamamoto-Furusho K, Moctezuma-Velázquez C, et all. The neutrophil-lymphocyte ratio as a predictor of steroid response in patients with severe ulcerative colitis: a retrospective cohort study. 9006/2022


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Publication history

Received: 14/06/2022

Accepted: 13/07/2022

Online First: 28/07/2022

Published: 03/04/2023

Article revision time: 24 days

Article Online First time: 44 days

Article editing time: 293 days


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