Year 2020 / Volume 112 / Number 1
Original
The association between de novo inflammatory bowel disease and celiac disease

7-11

DOI: 10.17235/reed.2019.5535/2018

Noemí Manceñido Marcos, Ramón Pajares Villarroya, Silvia Salinas Moreno, M. Rosario Arribas López, Carmen Comas Redondo,

Abstract
Introduction: controversial data have been reported on the potential association between celiac disease (CeD) and inflammatory bowel disease (IBD). Objective: to study the prevalence of CeD in patients newly diagnosed cases with IBD. Methods: an observational, retrospective study was performed in patients with newly diagnosed IBD who were screened for CeD by anti-tissue transglutaminase antibodies (anti-tTG) measurements and an endoscopic duodenal biopsy. No patients had received corticosteroids, immunosuppressants or biologic drugs within the three months prior to gastroscopy. In the presence of Marsh 1, other causes were ruled out. CeD was diagnosed in patients positive for anti-tTG, compatible duodenal biopsy findings and a good response to a gluten-free diet. Results: a total of 163 patients were screened for CeD. Of these, six (3.7%) were positive for anti-tTG and four were diagnosed with CeD (three had ulcerative colitis, one had Crohn’s disease). All patients with both CeD and IBD had normal IgA levels, positive anti-tTG and CeD genetic markers. Conclusions: the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD.
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Manceñido Marcos N, Pajares Villarroya R, Salinas Moreno S, Arribas López M, Comas Redondo C. The association between de novo inflammatory bowel disease and celiac disease . 5535/2018


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Publication history

Received: 11/02/2018

Accepted: 09/07/2019

Online First: 13/11/2019

Published: 10/01/2020

Article revision time: 509 days

Article Online First time: 640 days

Article editing time: 698 days


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