Year 2015 / Volume 107 / Number 9
Original
Contribution of KIR genes on the genetic predisposition to celiac disease and coexisting celiac disease and type 1 diabetes mellitus

547-553

DOI: 10.17235/reed.2015.3817/2015

H. HALUK AKAR,

Abstract
BACKGOUND and AIM: There are some common genetic features between celiac disease (CD) and diabetes mellitus type 1 (DM). However, the genetic risk factors have not been fully clarified for CD and the co-occurrence of CD and DM. KIR (killer immunoglobulin-like receptor) genes regulate the cytolitic activity of NK-cells and T lymphocytes. The aim of this study is to evaluate the contribution of KIR genes, KIR ligands, and combinations of KIR/KIR ligands on the genetic predisposition to CD and co-occurrence of CD and DM. MATERIAL AND METHODS: Forty six patients with CD (N=46), 20 patients with CD+DM (N=20), and 60 healthy controls (N=60) were included in this study. KIR genes and KIR ligands were investigated with PCR-SSOP and PCR-SSP in all subjects, respectively. RESULTS: This study showed that while the telomeric KIR genes (2DS5 and 3DS1), and combinations of 3DS1+HLA-BBw4-Thr- and 3DS1+HLA-BBw4-Iso- (p<0.001, p<0.001, p<0.001, and p<0.001, respectively) were observed more frequently in patients with CD than in controls, the 2DS5, 3DS1 KIR genes, C1 ligand, and combinations of 3DS1+HLA-BBw4-Thr- and 3DS1+HLA-BBw4-Iso- (p=0.002, p=0.004, p=0.036, p<0.001, and p=0.007, respectively) were observed more frequently in patients with CD+DM than in controls.
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9. Larizza D, Calcaterra V, Klersy C, et al. Common immunogenetic profile in children with multiple autoimmune diseases: thesignature of HLA-DQ pleiotropic genes. Autoimmunity 2012;45:470-5. DOI: 10.3109/08916934.2012.697594
10. Kotze LM, Nisihara R, Utiyama SR, et al. Absence of HLA-DQ2 and HLA-DQ8 does not exclude celiac disease in Brazilian patients. Rev Esp Enferm Dig 2014;106:561-2.
11. Fernández-Cavada-Pollo MJ, Alcalá-Peña MI, Vargas-Pérez ML, et al. Celiac disease and HLA-DQ genotype: Diagnosis of different genetic risk profiles related to the age in Badajoz, southwestern Spain. Rev Esp Enferm Dig 2013;105:469-76. DOI: 10.4321/S1130-01082013000800005
12. Lorinczy K, Juhász M, Csontos Á, et al. Does dermatitis herpetiformis result in bone loss as coeliac disease does? A cross sectional study. Rev Esp Enferm Dig 2013;105:187-93. DOI: 10.4321/S1130-01082013000400002
13. Shen Y, Cao D, Li Y, et al. Distribution of HLA-A, -B, and –C alleles and HLA/KIR combinations in Han population in China. Immunol Res 2014;2014:565296. DOI: 10.1155/2014/565296
14. Lanier LL. NK cell recognition. Annu Rev Immunol 2005;23:225-74. DOI: 10.1146/annurev.immunol.23.021704.115526
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17. Thielens A, Vivier E, Romagné F. NK cell MHC class I specific receptors (KIR): From biology to clinical intervention. Curr Opin Immunol 2012;24:239-45. DOI: 10.1016/j.coi.2012.01.001
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AKAR H. Contribution of KIR genes on the genetic predisposition to celiac disease and coexisting celiac disease and type 1 diabetes mellitus . 3817/2015


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Publication history

Received: 21/04/2015

Accepted: 13/05/2015

Online First: 26/05/2015

Published: 29/08/2015

Article revision time: 18 days

Article Online First time: 35 days

Article editing time: 130 days


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