Year 2020 / Volume 112 / Number 12
Original
IL-10 gene promoter region polymorphisms and their association with celiac disease

915-920

DOI: 10.17235/reed.2020.6286/2019

Miryan Susana López, María Mercedes Tiscornia, María Beatriz Dicarlos, Pedro Daría Zapata,

Abstract
Introduction: in celiac disease (CD), immune response activation results in local cytokine network impairment. Interleukin 10 (IL-10) is a key anti-inflammatory cytokine in the prevention of inflammatory conditions. Objective: to analyze the association of single nucleotide polymorphisms in the IL-10 gene promoter region with CD in a population of Misiones Province, Argentina. Patients and methods: DNA from whole blood was extracted from 40 patients with CD and 80 controls and the IL-10 gene promoter region containing polymorphisms rs1800896A/G, rs1800871T/C and rs1800872A/C was amplified. Risk was established by calculating odds ratios (OR) and statistical significance was considered as p < 0.05. Results: there were no significant differences in rs1800896 genotype distribution between celiac patients and controls. The frequency of the CC genotype for rs1800871T/C and rs1800872A/C was lower among celiac patients (35 % vs 65 %; p = 0.002). CD risk was associated with carriers of the more uncommon T allele of rs1800871T/C and the more uncommon A allele of rs1800872A/C, with a dominant model (OR = 2.79; 95 % CI: 1.27-6.09; p = 0.01). A risk effect was found for haplotype ATA (OR = 3.05; 95 % CI: 1.25-7.46; p = 0.01). Conclusion: carriers of the less common T allele of rs1800871T/C and the less common A allele of rs1800872A/C in the IL-10 gene promoter are at high risk of CD with a dominant model. There was no risk for rs1800896A/G. The ATA haplotype showed an association with CD development.
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López M, Tiscornia M, Dicarlos M, Zapata P. IL-10 gene promoter region polymorphisms and their association with celiac disease. 6286/2019


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Publication history

Received: 18/03/2019

Accepted: 11/02/2020

Online First: 15/10/2020

Published: 09/12/2020

Article revision time: 322 days

Article Online First time: 577 days

Article editing time: 632 days


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