Year 2021 / Volume 113 / Number 2
Letter
Effectiveness and safety of switching to adalimumab biosimilar ABP 501 in Crohn’s disease

154-155

DOI: 10.17235/reed.2020.7232/2020

Angelo Viscido, Giovanni Latella,

Abstract
We read with great interest the article “Effectiveness and safety of adalimumab biosimilar ABP 501 in Crohn’s disease: an observational study” by Ribaldone et al., which was recently published in your journal. The authors report the first real-life study of the adalimumab biosimilar ABP 501 in Crohn’s disease (CD). The study investigated the short-term effectiveness and safety of ABP 501 in 87 patients with CD, 25 patients naïve to adalimumab and 62 switched from the adalimumab originator. A meaningful proportion of CD patients treated with ABP 501 showed clinical benefit with a satisfactory safety profile until the end of follow-up.
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References
1. Ribaldone DG, Caviglia GP, Pellicano R, et al. Effectiveness and safety of adalimumab biosimilar ABP 501 in Crohn's disease: an observational study. Rev Esp Enferm Dig 2020; 112: 195-200. DOI: 10.17235/reed.2020.6693/2019.
2. Fiorino G, Caprioli F, Daperno M, et al. Use of biosimilars in inflammatory bowel disease: a position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Dig Liver Dis 2019; 51: 632-639. DOI: 10.1016/j.dld.2019.02.004.
3. Liu J, Eris T, Li C, et al. Assessing analytical similarity of proposed amgen biosimilar ABP 501 to adalimumab. BioDrugs 2016; 30: 321-38. DOI: 10.1007/s40259-016-0184-3.
4. Velayudhan J, Chen YF, Rohrbach A, et al. Demonstration of functional similarity of proposed biosimilar ABP 501 to adalimumab. BioDrugs 2016; 30: 339-51. DOI: 10.1007/s40259-016-0185-2.
5. Kaur P, Chow V, Zhang N, et al. A randomised, single-blind, single-dose, three-arm, parallel-group study in healthy subjects to demonstrate pharmacokinetic equivalence of ABP 501 and adalimumab. Ann Rheum Dis 2017; 76: 526-533. DOI: 10.1136/annrheumdis-2015-208914. Epub 2016 Jul 27.
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Viscido A, Latella G. Effectiveness and safety of switching to adalimumab biosimilar ABP 501 in Crohn’s disease. 7232/2020


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Publication history

Received: 06/05/2020

Accepted: 12/05/2020

Online First: 19/11/2020

Published: 08/02/2021

Article Online First time: 197 days

Article editing time: 278 days


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