Year 2018 / Volume 110 / Number 8
Letter
Sweet syndrome after treatment with vedolizumab in a patient with Crohn’s disease

530

DOI: 10.17235/reed.2018.5603/2018

Blanca Martínez Andrés, Violeta Sastre Lozano, José Francisco Sánchez Melgarejo,

Abstract
Sweet syndrome is a common extraintestinal manifestation in inflammatory bowel disease (IBD). In this research, a 42-year-old man case with colon Crohn's disease is been described. After failure with two anti-TNF therapies, in treatment with azathioprim, it was decided to start a therapeutic target change to Vedolizumab due to a severe outbreak refractory to corticosteroids. 24 hours after the infusion of the new drug, skin lesions appear along with leukocytes with neutrophilia, all suggestive of sweet syndrome later confirmed by histology. In this clinical case, the importance of knowing the possible side effects of recently commercialized drugs for IBD is shown, being this topic important for gastroenterologists due to the wide therapeutic arsenal that is becoming available for this pathology.
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References
1- Olmedo-Martín RV, Amo-Trillo V, González-Grande R et al. Efficacy and safety of vedolizumab as a treatment option for moderate to severe refractory ulcerative colitis in two patients after liver transplant due to primary sclerosing cholangitis. Rev Esp Enferm Dig 2017;109(9):659-62.
2- Ortega-Alonso A, López-Navarro N, Gallego E et al. Crohn's disease and Sweet's syndrome: A debut together. Rev Esp Enferm Dig. 2015;107(12):765-6.
3- Catalán-Serra I, Martín-Moraleda L, Navarro-López L et al. Crohn's disease and Sweet's syndrome: an uncommon association. Rev Esp Enferm Dig. 2010;102(5):331-7.
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Martínez Andrés B, Sastre Lozano V, Sánchez Melgarejo J. Sweet syndrome after treatment with vedolizumab in a patient with Crohn’s disease. 5603/2018


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Publication history

Received: 15/03/2018

Accepted: 22/03/2018

Online First: 14/06/2018

Published: 30/07/2018

Article Online First time: 91 days

Article editing time: 137 days


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