Year 2021 / Volume 113 / Number 5
Original
Normalization of long-term quality of life in Crohn’s disease patients receiving ustekinumab

313-317

DOI: 10.17235/reed.2020.6941/2020

Miquel Marquès-Camí, Virginia Robles Alonso, Natalia Borruel, Claudia Herrera de Guise, Luis Mayorga, Francesc Casellas,

Abstract
Background and aim: ustekinumab is a fully human monoclonal antibody against IL-12/23, approved for induction and maintenance treatment of Crohn’s disease (CD). Real-life data shows its true effectiveness in terms of clinical and endoscopic response. However, there is little information regarding health-related quality of life (HRQoL) in CD patients receiving ustekinumab. The main aim of this study was to define long-term clinical remission and HRQoL normalization. The clinical predictive factors of clinical remission were investigated as a secondary aim. Methods: a retrospective, observational study was performed in CD patients under ustekinumab treatment in the Hospital Vall d’Hebron, between January 2009 and January 2019. Clinical remission was defined using the Crohn’s Disease Activity Index (CDAI) and HRQoL normalization was defined by the 36-item Inflammatory Bowel Disease Questionnaire (IBDQ). Results: thirty-three patients were included. The average disease evolution was eleven years (standard deviation [SD]: 8), perianal disease was present in 13 patients (39 %), 30 patients (91 %) had previously been treated with alfa tumor necrosis factor antagonists (anti-TNF) agents and 22 patients (67 %) had a history of intestinal resection. Twenty-four patients (73 %) had undergone one year of treatment. Seventeen patients (51 %) reached clinical remission and six (18 %) restored the HRQoL. No predictors of clinical remission were identified. Conclusions: ustekinumab shows clinical effectiveness in real-life conditions similar to previous data. Normalization of HRQoL is low compared to clinical remission, which may be due to the inaccuracy of the indicator and the severe disease course. Such normalization is a challenge for physicians dealing with inflammatory bowel diseases.
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Marquès-Camí M, Robles Alonso V, Borruel N, Herrera de Guise C, Mayorga L, Casellas F, et all. Normalization of long-term quality of life in Crohn’s disease patients receiving ustekinumab. 6941/2020


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Publication history

Received: 04/02/2020

Accepted: 26/05/2020

Online First: 20/11/2020

Published: 10/05/2021

Article revision time: 106 days

Article Online First time: 290 days

Article editing time: 461 days


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