Year 2023 / Volume 115 / Number 3
Letter
Successful treatment of Crohn’s disease, aseptic liver abscess and psoriasis with ustekinumab

155-156

DOI: 10.17235/reed.2022.9155/2022

Cong Dai, Yu-hong Huang,

Abstract
Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract that is commonly known to affect the ileum and colon. Aseptic abscess (AA) has been pathologically described as sterile abscess with a predominance of polymorphonuclear leucocyte infiltrates, and is considered a rare extraintestinal manifestation of CD. AA presents a great challenge to physicians in determining if it is an extraintestinal manifestation of CD or an actual infection with pathogenic microorganisms. There is a strong association between CD and psoriasis. But the coexistence of AA and psoriasis in CD was unusual. Ustekinumab, as an IL 12/23 inhibitor, is the only treatment with a similar mechanism currently available for both CD and psoriasis. We report a case of successful use of ustekinumab to treat a CD patient with hepatic AA and psoriasis.
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References
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3. Andre MFJ, Piette JC, Kemeny JL, Ninet J, Jego P, Delevaux I, Wechsler B, Weiller PJ, Frances C, Bletry O, Wismans PJ, Rousset H, Colombel JF, Aumaitre O. Aseptic abscesses: a study of 30 patients with or without inflammatory bowel disease and review of the literature. Medicine (Baltimore) 2007;86:145-161.
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Dai C, Huang Y. Successful treatment of Crohn’s disease, aseptic liver abscess and psoriasis with ustekinumab . 9155/2022


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Publication history

Received: 26/08/2022

Accepted: 29/08/2022

Online First: 12/09/2022

Published: 07/03/2023

Article Online First time: 17 days

Article editing time: 193 days


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