Year 2023 / Volume 115 / Number 6
Letter
Efficacy and safety of intravenous ustekinumab maintenance therapy in Crohn’s disease.

340-341

DOI: 10.17235/reed.2023.9594/2023

Benito Hermida Pérez, Alejo Mancebo Mata, Miguel Ángel de Jorge Turrión, Pilar Varela Trastoy,

Abstract
Crohn’s disease is a chronic multifactorial disease for which therapeutic options have expanded in the last decades. However there are still patients who lack or lose response to current standard treatment strategies. A unicentric, retrospective, study was performed in order to evaluate the clinical and biochemical response to intravenous ustekinumab manteinance therapy (IVUMT) in patients with refractory CD. We included 12 patients from our centre who started IVUMT between September 2018 and November 2021. 75% started IV treatment after previous subcutaneous (SC) treatment. At week 8 (n=8), 63% had clinical response, with 25% in clinical remission. At week 16 (n=10), 60% had clinical response, with 50% in clinical remission. At week 26 (n=10), 90% had clinical response, with 60% in clinical remission. At week 52 (n=11), 91% had clinical response, with 64% in clinical remission (Fig. 2). Basal faecal calprotectin (FCP) median level was 684µg/g, with a significant reduction at 52 weeks, with median FCP 97µg/g (p=0,017). Basal C-reactive protein (CRP) median level was 11,6mg/L. A significant reduction was observed at week 26, with median CRP 2,8mg/L (p=0,008); and 52 weeks, with median CRP 2,7 (p=0,013). Average follow-up was 117,1 weeks, average treatment survival was 105,9 weeks. There were no severe adverse events. Our results suggest IVUMT is a safe and effective treatment for most patients with refractory and complex CD and should be considered as an option in selected patients.
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References
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Hermida Pérez B, Mancebo Mata A, de Jorge Turrión M, Varela Trastoy P. Efficacy and safety of intravenous ustekinumab maintenance therapy in Crohn’s disease.. 9594/2023


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Publication history

Received: 13/03/2023

Accepted: 15/03/2023

Online First: 28/03/2023

Published: 06/06/2023

Article Online First time: 15 days

Article editing time: 85 days


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