Year 2024 / Volume 116 / Number 11
Letter
A novel nomogram for predicting endoscopic remission in refractory Crohn’s disease with ustekinumab administration

644-645

DOI: 10.17235/reed.2024.10212/2023

Sucong Lyu, Guoqiang Zhong, Yangda Song, Yan Sun, Jin Li, Xiujing Fan, Qing Qing, Mingsong Li,

Abstract
Ustekinumab (UST) is a human IgG1 monoclonal antibody that targets to the share p40 subunit of interleukin-12(IL-12) and IL-23. Evidence has shown that UST therapy is well tolerated and effective in inducing clinical response in refractory CD(Crohn’s disease) and dose escalation is effective in recapturing response in over half of the patients. However, no predictive factor has been reported to be helpful for UST treatment in clinical practice. Additionally, there were few reports about therapeutic drug monitoring (TDM) of UST administration in China due to its late launch time in Chinese market and lack of experience in clinical use. Herein, we establish and validate the first UST-trough concentrations (TCs) -related nomogram in China for predicting endoscopic remission in refractory CD to facilitate clinical decision making.
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References
1. Lorenzo Gonzalez L, Valdes Delgado T, Vazquez Moron JM, et al. Ustekinumab in Crohn's disease: real-world outcomes and predictors of response. Rev Esp Enferm Dig. 2022;114(5):272-9.
2. Olmedo Martin RV, Vazquez Moron JM, Martin Rodriguez MDM, et al. Effectiveness and safety of ustekinumab dose escalation in Crohn's disease: a multicenter observational study. Rev Esp Enferm Dig. 2023;115(12):686-92.
3. Gisbert JP, Chaparro M. Predictors of Primary Response to Biologic Treatment [Anti-TNF, Vedolizumab, and Ustekinumab] in Patients With Inflammatory Bowel Disease: From Basic Science to Clinical Practice. J Crohns Colitis. 2020;14(5):694-709.
4. Yao JY, Zhang M, Wang W, et al. Ustekinumab trough concentration affects clinical and endoscopic outcomes in patients with refractory Crohn's disease: a Chinese real-world study. BMC Gastroenterol. 2021;21(1):380.
5. Yao J, Zhang H, Su T, et al. Ustekinumab Promotes Radiological Fistula Healing in Perianal Fistulizing Crohn's Disease: A Retrospective Real-World Analysis. J Clin Med. 2023;12(3).
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Citation tools
Lyu S, Zhong G, Song Y, Sun Y, Li J, Fan X, et all. A novel nomogram for predicting endoscopic remission in refractory Crohn’s disease with ustekinumab administration. 10212/2023


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Publication history

Received: 26/12/2023

Accepted: 27/12/2023

Online First: 18/01/2024

Published: 11/11/2024

Article Online First time: 23 days

Article editing time: 321 days


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