Year 2020 / Volume 112 / Number 8
Original
Predictive factors of clinical response to treatment with anti-TNF agents in ulcerative colitis: what have we learned from our patients?

636-641

DOI: 10.17235/reed.2020.6688/2019

Laura Ramos, Alejandro Hernández Camba, Raquel de la Barreda Heusser, Milagros Vela, Inmaculada Alonso-Abreu, Esther Rodríguez G., Marta Carrillo, Carlos Tardillo, Yolanda Rodríguez, Andrés Figueroa Marrero, Daniel Ceballos, Noelia Cruz, Lilian Kolle-Casso, Alejandro Jiménez Sosa,

Abstract
Introduction: inhibitors of tumor necrosis factor alpha (anti-TNFs) are effective drugs for the treatment of moderate-to-severe ulcerative colitis (UC). However, many patients do not respond or lose therapeutic response during follow-up. Objectives: to analyze the determining factors of clinical response to anti-TNFs in UC. Methods: a multicenter retrospective study was performed in 79 patients with UC who started treatment with anti-TNFs between 2009 and 2015. The primary endpoint was clinical remission (pMayo index ≤ 1) at 12 months. Furthermore, remission and clinical response (final pMayo score ≤ 3) and corticoids discontinuation were assessed at three, six and 12 months. An analysis was performed to identify variables predictive of clinical response. Results: at 12 months, remission and clinical response were seen in 59.2 % and 77.8 % of patients, respectively. Corticoids could be discontinued in 82.4 % of patients. At 12 months, corticoids discontinuation (< 3 months) (OR 0.06; 95 % CI: 0.01-0.24) and clinical response at six months (OR 0.008; 95 % CI: 0.001-0.053) were independent factors predictive of clinical remission. Conclusion: in patients with active UC on anti-TNFs, corticoid discontinuation within three months and clinical response at six months after treatment onset are predictive of clinical disease remission.
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Ramos L, Hernández Camba A, de la Barreda Heusser R, Vela M, Alonso-Abreu I, Rodríguez G. E, et all. Predictive factors of clinical response to treatment with anti-TNF agents in ulcerative colitis: what have we learned from our patients?. 6688/2019


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Publication history

Received: 16/10/2019

Accepted: 09/01/2020

Online First: 24/06/2020

Published: 30/07/2020

Article revision time: 73 days

Article Online First time: 252 days

Article editing time: 288 days


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