Year 2024 / Volume 116 / Number 2
Original
Ulcerative colitis overall disease severity index predicts colectomy: a prospective cohort study

77-82

DOI: 10.17235/reed.2023.9754/2023

Shengduo He, Hong Jiang, Yu Tian, Wei Zhang, Guigen Teng, Huahong Wang,

Abstract
Background: ulcerative colitis (UC) overall disease severity index (DSI) has been established. A prospective cohort study was performed to find the value of DSI to predict colectomy within one and four years and explored the association between DSI and other indexes. Methods: the hospitalized UC patients were enrolled from March 2018 to January 2019 in this single center study. DSI, Truelove and Witts criteria, Mayo index and Seo index were assessed by medical records. Outcome was whether to undergo colectomy within one and four years and was obtained by telephone survey or medical records. Index values of predicting colectomy within one and four years were evaluated using receiver operating characteristics (ROC) curves. Results: one hundred and thirty-eight of 233 hospitalized UC patients were enrolled. Within one year, the follow-up period was less than one year for six patients and two patients had died. A further nine patients underwent colectomy. The Spearman correlation coefficient between DSI and Truelove and Witts criteria, Mayo index and Seo index were 0.730, 0.839 and 0.843, respectively. Using these indices to predict colectomy within one and four years, the area under the curve of DSI was more than those of other indices and the cut-off value of DSI was 79. Conclusions: a good correlation of DSI with other indexes was demonstrated. DSI can be used to predict the need for colectomy within one or four years.
Lay Summary
Ulcerative colitis (UC) overall disease severity index (DSI) has been established. This study identified the value of DSI to predict colectomy within one and four years and explored the association between DSI and other indexes. The hospitalized UC patients were enrolled from March 2018 to January 2019 in this single center study. DSI and other indexes were assessed by medical records. Outcome was whether to undergo colectomy within one and four years and was obtained by telephone survey or medical records. The index value of predicting colectomy within one and four years was evaluated using receiver operating characteristics (ROC) curves. We enrolled 138 of 233 hospitalized UC patients. Nine patients underwent colectomy within one year. The Spearman correlation coefficient between DSI and Truelove&Witts criteria, Mayo index and Seo index was 0.730, 0.839, and 0.843, respectively. Using these indexes to predict colectomy within one and four years, the area under the curve of DSI was more than those of other indexes. We demonstrated DSI had a good correlation with other indexes. DSI can be used to predict the need for colectomy within one or four years.
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Publication history

Received: 30/05/2023

Accepted: 20/08/2023

Online First: 14/09/2023

Published: 07/02/2024

Article revision time: 70 days

Article Online First time: 107 days

Article editing time: 253 days


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