Year 2024 / Volume 116 / Number 11
Letter
Long-term remission achieved in a rare case of pyoderma gangrenosum and ulcerative colitis with surgery and postoperative infliximab

638-640

DOI: 10.17235/reed.2024.10144/2023

Xiaofang Xu, Xiaodan Lv, Zhixi Huang, Bing Han, Ziqian Huang, Shiquan Li, Junhua Fan, Xiaoping Lv,

Abstract
Background Pyoderma gangrenosum (PG) is a rare extraintestinal manifestation of inflammatory bowel disease. In recent years, the use of biologics in PG has been on the rise and has shown promising results. The surgical treatment of PG remains a topic of debate, with limited reports on the use of postoperative biologic therapy. Case report: This case report describes a 52-year-old woman who presented with multiple skin ulcers, pus discharge, and bloody diarrhea. The patient was diagnosed with PG with ulcerative colitis based on medical history, ulcer appearance, histopathology, treatment response, and the presence of ulcerative colitis. Surgical intervention was performed to repair the ulcers and amputate the fourth finger and fourth toe of both feet. Additionally, infliximab induction therapy was initiated two weeks after the surgery. The patient's intestinal symptoms demonstrated improvement, and after 10 months of treatment, the lesions were completely healed with no recurrence of skin ulcers. Conclusions This case report highlights a rare instance of successful treatment for PG with ulcerative colitis through a combination of surgery and postoperative infliximab.
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Xu X, Lv X, Huang Z, Han B, Huang Z, Li S, et all. Long-term remission achieved in a rare case of pyoderma gangrenosum and ulcerative colitis with surgery and postoperative infliximab . 10144/2023


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Publication history

Received: 06/12/2023

Accepted: 15/12/2023

Online First: 11/01/2024

Published: 11/11/2024

Article Online First time: 36 days

Article editing time: 341 days


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