Year 2024 / Volume 116 / Number 7
Letter
Proton pump inhibitors (PPIs) and cancer. What should patients with gastroesophageal reflux disease candidates for PPIs therapy who refuse to comply with treatment know?

395-396

DOI: 10.17235/reed.2023.9944/2023

José Ruiz Pardo, Pedro Antonio Sánchez Fuentes, Ricardo Belda Lozano, Elisabet Vidaña Márquez,

Abstract
The relationship of proton pump inhibitors (PPIs) with gastric cancer is not clear. However, more and more patients with gastroesophageal reflux disease (GERD) who are candidates for therapy with PPIs reject such treatment. This situation is largely caused by global access to information, especially on the internet, where some news has recently been published linking PPIs to the development of gastric cancer. For this reason, patients with GERD who are candidates for therapy with PPIs, before rejecting such treatment and opting for antireflux surgery, should be aware of the morbidity and mortality of the surgery and the current scientific evidence regarding the relationship between PPIs and gastric cancer.
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References
1. Martín de Argila de Prados C, López Cardona J, Argüelles-Arias F. Safe use of proton-pump inhibitors. Rev Esp Enferm Dig. 2023;115:475-9.
2. Yadlapati R, Hungness ES, Pandolfino JE. Complications of Antireflux Surgery. Am J Gastroenterol. 2018;113:1137-47.
3. Eusebi LH, Rabitti S, Artesiani ML, et al. Proton pump inhibitors: Risks of long-term use. J Gastroenterol Hepatol. 2017;32:1295-1302.
4. Malfertheiner P, Megraud F, Rokkas T, et al; European Helicobacter and Microbiota Study group. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;71:1724-62.
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Citation tools
Ruiz Pardo J, Sánchez Fuentes P, Belda Lozano R, Vidaña Márquez E. Proton pump inhibitors (PPIs) and cancer. What should patients with gastroesophageal reflux disease candidates for PPIs therapy who refuse to comply with treatment know?. 9944/2023


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Publication history

Received: 07/09/2023

Accepted: 14/09/2023

Online First: 26/10/2023

Published: 08/07/2024

Article Online First time: 49 days

Article editing time: 305 days


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