Year 2019 / Volume 111 / Number 3
Original
Is prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer?

189-192

DOI: 10.17235/reed.2018.5831/2018

Vicente Munitiz Ruiz, Pilar Jimeno, David Ruiz de Angulo, Ángeles Ortiz, Luisa F. Martínez de Haro, Miguel Marín, Pedro Cascales, Gema Ruiz García, Eduardo Ortiz Ruiz, Pascual Parrilla,

Abstract
Introduction: hereditary diffuse gastric cancer (HDGC) is a recently reported hereditary cancer syndrome. Patients with suspected HDGC must be under surveillance via endoscopy and multiple biopsies. As an alternative, some studies suggest prophylactic gastrectomy (PG) for disease carriers. The goal of this article was to report our experience with a CDH1 mutation positive family who underwent PG. Patients and methods: the index case was a 34-year-old female diagnosed with diffuse gastric adenocarcinoma and massive carcinomatosis. There was a family history of gastric adenocarcinoma in seven family members. A genetic study identified the c.1577G>A mutation, in exon 11 of the CDH1 gene via sequencing analysis. Results: this mutation was also present in other six family members, who subsequently underwent prophylactic gastrectomy. The pathology study of resected gastric segments revealed multiple microscopic foci of adenocarcinoma in five of these individuals. These foci were not detected in the multiple endoscopies performed before surgery. Conclusions: we recommend prophylactic gastrectomy for CDH1 mutation carriers even in the absence of lesions during endoscopic screening.
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Munitiz Ruiz V, Jimeno P, Ruiz de Angulo D, Ortiz Á, Martínez de Haro L, Marín M, et all. Is prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer?. 5831/2018


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Publication history

Received: 17/07/2018

Accepted: 26/08/2018

Online First: 23/11/2018

Published: 04/03/2019

Article revision time: 35 days

Article Online First time: 129 days

Article editing time: 230 days


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