Year 2019 / Volume 111 / Number 11
Review
Association between gastroesophageal reflux disease and atrial fibrillation: a systematic review and meta-analysis

874-879

DOI: 10.17235/reed.2019.5389/2017

Lu Xu, Yu Zhang, Jiarong Xie, Yi Liu, Lei Xu,

Abstract
Background and objective: associations between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) are inconclusive. Some studies found that AF was a risk factor for GERD whereas other studies showed opposite results. The primary objective of this study was to systematically evaluate whether GERD and AF have a bidirectional association using a meta-analysis. Methods: a systematic review was conducted of studies on the association between GERD and AF, written in the English language and included in Cochrane CENTRAL, PubMed and EMBASE until February 2017. The search was limited to longitudinal, case-control, and cross-sectional studies. Results: among 548 studies found in the above-mentioned databases, seven fulfilled the inclusion criteria. Among these seven studies, two were longitudinal studies, two were case-control studies, and three were cross-sectional studies. The summary adjusted relative risks (RRs) for AF-induced GERD and GERD-induced AF were 1.54 (95% CI, 1.08-2.17) and 1.06 (95% CI, 0.86-1.31), respectively. The subgroup analysis showed that the associations were not significantly modified by sample size, study design, age, or geographic area. Conclusions: this meta-analysis supported the association of AF with increased risk of GERD.
Share Button
New comment
Comments
No comments for this article
References
1. El-Serag HB, Sweet S, Winchester CC, et al. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2014;63(6):871-80. doi: 10.1136/gutjnl-2012-304269.
2. Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101(8):1900-20; quiz 1943. doi: 10.1111/j.1572-0241.2006.00630.x.
3. Lloyd-Jones DM, Wang TJ, Leip EP, et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004;110(9):1042-6. doi: 10.1161/01.CIR.0000140263.20897.42.
4. Camm AJ, Lip GY, De Caterina R, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation--developed with the special contribution of the European Heart Rhythm Association. Europace 2012;14(10):1385-413. doi: 10.1093/europace/eus305.
5. Benjamin EJ, Levy D, Vaziri SM, et al. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. Jama 1994;271(11):840-4.
6. Schnabel RB, Sullivan LM, Levy D, et al. Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet 2009;373(9665):739-45. doi: 10.1016/s0140-6736(09)60443-8.
7. Jervell O,Lodoen O. The gastrocardiac syndrome. Acta Med Scand Suppl 1952;266:595-9.
8. Bunch TJ, Packer DL, Jahangir A, et al. Long-term risk of atrial fibrillation with symptomatic gastroesophageal reflux disease and esophagitis. Am J Cardiol 2008;102(9):1207-11. doi: 10.1016/j.amjcard.2008.06.048.
9. Kunz JS, Hemann B, Edwin Atwood J, et al. Is there a link between gastroesophageal reflux disease and atrial fibrillation? Clin Cardiol 2009;32(10):584-7. doi: 10.1002/clc.20660.
10. Shimazu H, Nakaji G, Fukata M, et al. Relationship between atrial fibrillation and gastroesophageal reflux disease: a multicenter questionnaire survey. Cardiology 2011;119(4):217-23. doi: 10.1159/000331497.
11. Huang CC, Chan WL, Luo JC, et al. Gastroesophageal reflux disease and atrial fibrillation: a nationwide population-based study. PLoS One 2012;7(10):e47575. doi: 10.1371/journal.pone.0047575.
12. Kubota S, Nakaji G, Shimazu H, et al. Further assessment of atrial fibrillation as a risk factor for gastroesophageal reflux disease: a multicenter questionnaire survey. Intern Med 2013;52(21):2401-7.
13. Hwang JJ, Lee DH, Yoon H, et al. Is Atrial Fibrillation a Risk Factor for Gastroesophageal Reflux Disease Occurrence? Medicine (Baltimore) 2015;94(43):e1921. doi: 10.1097/md.0000000000001921.
14. Floria M, Barboi O, Grecu M, et al. Atrial fibrillation and sympathovagal balance in patients with gastroesophageal reflux disease. Turk J Gastroenterol 2017;28(2):88-93. doi: 10.5152/tjg.2017.16540.
15. Shimazu H, Nakaji G, Fukata M, et al. Relationship between atrial fibrillation and gastroesophageal reflux disease: a multicenter questionnaire survey. Cardiology 2011;119(4):217-23. doi: 10.1159/000331497.
16. Armaganijan L, Patel D, Lopes RD, et al. Gastroesophageal reflux and atrial fibrillation: is there any correlation? Expert Rev Cardiovasc Ther 2012;10(3):317-22. doi: 10.1586/erc.11.198.
17. Chen Y. Gastroesophageal reflux disease and non-digestive tract diseases. Expert Rev Gastroenterol Hepatol 2015;9(5):685-92. doi: 10.1586/17474124.2015.1012495.
18. Linz D, Hohl M, Vollmar J, et al. Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction. Europace 2017;19(1):16-20. doi: 10.1093/europace/euw092.
19. Roman C, Bruley des Varannes S, Muresan L, et al. Atrial fibrillation in patients with gastroesophageal reflux disease: a comprehensive review. World J Gastroenterol 2014;20(28):9592-9. doi: 10.3748/wjg.v20.i28.9592.
20. Velagapudi P, Turagam MK, Leal MA, et al. Atrial fibrillation and acid reflux disease. Clin Cardiol 2012;35(3):180-6. doi: 10.1002/clc.21969.
21. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. Jama 2000;283(15):2008-12.
22. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25(9):603-5. doi: 10.1007/s10654-010-9491-z.
23. MathWorks. Normal inverse cumulative distribution function. 2018. URL:https://ww2.mathworks.cn/help/stats/norminv.htmlresponsive_offcanvas.
24. Higgins JP,Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21(11):1539-58. doi: 10.1002/sim.1186.
25. Chen GC, Zhang ZL, Wan Z, et al. Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis. Cancer Causes Control 2015;26(12):1719-28. doi: 10.1007/s10552-015-0665-6.
26. DerSimonian R,Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7(3):177-88.
27. Begg CB,Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50(4):1088-101.
28. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. Bmj 1997;315(7109):629-34.
Related articles

Letter

Histiocytic sarcoma of the esophagus

DOI: 10.17235/reed.2022.9296/2022

Digestive Diseases Image

A rare endoscopic pattern in a patient with gastroesophageal reflux disease

DOI: 10.17235/reed.2022.9124/2022

Digestive Diseases Image

Severe drug esophagitis in a patient with achalasia

DOI: 10.17235/reed.2022.8476/2021

Digestive Diseases Image

Acute phlegmonous esophagitis: apropos of a case

DOI: 10.17235/reed.2020.6742/2019

Letter

Familial dysphagia: eosinophilic esophagitis

DOI: 10.17235/reed.2019.6610/2019

Case Report

Emphysematous esophagitis with gastric perforation

DOI: 10.17235/reed.2019.6322/2019

Letter

Symptomatic exfoliative esophagitis induced by dabigatran

DOI: 10.17235/reed.2018.5747/2018

Letter to the Editor

Eosinophilic esophagitis and herpetic esophagitis: cause or consequence?

DOI: 10.17235/reed.2017.4616/2016

Letter to the Editor

A complication following a biopsy sample in eosinophilic esophagitis

DOI: 10.17235/reed.2017.4560/2016

Review

Impaired esophageal motor function in eosinophilic esophagitis

DOI: 10.17235/reed.2015.3801/2015

Citation tools
Xu L, Zhang Y, Xie J, Liu Y, Xu L. Association between gastroesophageal reflux disease and atrial fibrillation: a systematic review and meta-analysis. 5389/2017


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1629 visits.
This article has been downloaded 294 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 21/11/2017

Accepted: 10/04/2019

Online First: 16/10/2019

Published: 07/11/2019

Article revision time: 495 days

Article Online First time: 694 days

Article editing time: 716 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology