Year 2024 / Volume 116 / Number 6
Letter
Lymphoepithelioma-like gastric adenocarcinoma. Descriptive case series

347-348

DOI: 10.17235/reed.2023.9768/2023

Manuel García-Redondo, Pedro Antonio Sánchez-Fuentes, José Ruiz Pardo, Elisabet Vidaña-Márquez, Ricardo Belda Lozano, Manuel Ferrer-Márquez, Ángel Reina Duarte,

Abstract
Lymphoepithelioma-like gastric adenocarcinoma is characterised by a large reactive lymphoplasmacytic infiltrate in the stroma and islets of undifferentiated cells, which express intense and widespread Epstein-Barr virus (EBV). This tumour type has higher survival rates than other gastric cancers, a more proximal location and less lymphatic spread. Our aim is to describe the clinical and pathological characteristics of our series of lymphoepithelioma-like gastric adenocarcinoma. We selected patients who underwent surgery for gastric adenocarcinoma lymphoepithelioma-like variant from 2014 onwards. The results of the following variables were collected: age (years), sex, pre-diagnostic clinical time (months), gastric tumour location, endoscopic biopsy histology, surgical technique, in situ hybridisation for EBER region (Epstein-Barr virus-associated non-coding RNA), microsatellite instability, degree of differentiation, level of resection, tumour size (cm), TNM T value, lymphadenopathy/resected node ratio, overall survival (months) and vital status. Our experience in the lymphoepithelioma-like variant presents as an advanced gastric cancer, possibly related to long-standing prediagnostic symptoms. It behaves as a tumour with expansive local growth with little capacity for lymphatic or metastatic involvement, which could be explained by the prominent intratumoral lymphoid stroma that acts as an antimetastatic barrier.
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References
1. Chaparro Mirete M, López-López V, Robles Campos R. Lymphoepithelioma-like carcinoma of the duodenum: a very infrequent tumor. Rev Esp Enferm Dig. 2020;112(3):239. 10.17235/reed.2020.6503/2019.
2. Herath CHP, Chetty R. Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma. Arch Pathol Lab Med [Internet]. 2008;132(4):706–9.
3. Park S, Choi M-G, Kim K-M, Kim HS, Jung S-H, Lee JH, et al. Lymphoepithelioma-like carcinoma: a distinct type of gastric cancer. J Surg Res [Internet]. 2015;194(2):458–63.
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Citation tools
García-Redondo M, Sánchez-Fuentes P, Ruiz Pardo J, Vidaña-Márquez E, Belda Lozano R, Ferrer-Márquez M, et all. Lymphoepithelioma-like gastric adenocarcinoma. Descriptive case series. 9768/2023


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Publication history

Received: 03/06/2023

Accepted: 11/06/2023

Online First: 22/06/2023

Published: 04/06/2024

Article Online First time: 19 days

Article editing time: 367 days


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