Year 2024 / Volume 116 / Number 11
Letter
An Epstein-Barr virus-positive mucocutaneous ulcer in a patient with ulcerative colitis: a recently described entity to take into account

645-646

DOI: 10.17235/reed.2024.10168/2023

Álvaro Yagüe Parada, Orencio Bosch Esteva, Daniel Calero Barón, Andrea Blanco Fernández, Víctor Manuel Castellano Megías, Sara Aurora Rodríguez Vargas,

Abstract
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a new entity recently included in the classification of B-cell lymphoproliferative disorders associated with Epstein-Barr virus (EBV). It is related to immunosuppression and it usually appears in the oropharynx or the skin, being the colon an uncommon location. We present the case of a 31-year-old man with ulcerative proctitis being treated with azathioprine (AZA) and adalimumab (ADA), who was admitted to the hospital due to suspicion of a moderate-severe flare of ulcerative proctitis. Microbiological stool analyses were negative, with a positive fecal calprotectin test (2700 mg/kg). Rectoscopy showed severe endoscopic activity, taking multiple biopsies. Intravenous steroids were started at a dose of 60 mg/day. He presented a favorable clinical and analytical evolution, being discharged from the hospital. The histological results were received at gastroenterology consultation, being compatible with EBVMCU. AZA and ADA were withdrawn, whereas descending steroid regimen and oral and topical mesalazine were continued, being the clinical response adequate.
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References
Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, Jaffe ES. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019 Apr 18;133(16):1703-1714. doi: 10.1182/blood-2018-11-881268. Epub 2019 Jan 11. Erratum in: Blood. 2019 Sep 26;134(13):1112. PMID: 30635287; PMCID: PMC6473500.
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Citation tools
Yagüe Parada Á, Bosch Esteva O, Calero Barón D, Blanco Fernández A, Castellano Megías V, Rodríguez Vargas S, et all. An Epstein-Barr virus-positive mucocutaneous ulcer in a patient with ulcerative colitis: a recently described entity to take into account. 10168/2023


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Publication history

Received: 13/12/2023

Accepted: 19/12/2023

Online First: 23/01/2024

Published: 11/11/2024

Article Online First time: 41 days

Article editing time: 334 days


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