Year 2021 / Volume 113 / Number 3
Letter
Epstein-Barr virus-positive mucocutaneous ulcer mimicking sigmoid colon adenocarcinoma

225-226

DOI: 10.17235/reed.2020.7272/2020

Juan Diego Castro Limo, Cristian Alexander Sierra Bernal, Elena Martínez Zamorano,

Abstract
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) belongs to a spectrum of EBV-associated lymphoproliferative disease. We present the case of an 89-year-old female with seronegative polyarthritis treated for several years with methotrexate (12.5 mg weekly). She also had asthenia, anorexia and a positive fecal immunohistochemical test. In view of the above, a colonoscopy was performed that revealed a polypoid mass with a malignant appearance in the sigmoid colon, which prevented the passage of the endoscope and was suggestive of colonic adenocarcinoma (CAC).
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References
(1) Roberts T, Chen X, Liao J. Diagnostic and therapeutic challenges of EBV-positive mucocutaneous ulcer: a case report and systematic review of the literature. Exp Hematol Oncol. 2016; 5: 13. DOI: 10.1186/s40164-016-0042-5.
(2) Allen PB, Laing G, Connolly A, et al. EBV-associated colonic B-cell lymphoma following treatment with infliximab for IBD: a new problem? BMJ Case Rep. 2013. Published online: Sept 2013; DOI: 10.1136/bcr-2013-200423.
(3) Gru A, Jaffe ES. Cutaneous EBV-related lymphoproliferative disorders. Semin Diagn Pathol, 2017; 1: 60-75. DOI: 10.1053/j.semdp.2016.11.003.
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Castro Limo J, Sierra Bernal C, Martínez Zamorano E. Epstein-Barr virus-positive mucocutaneous ulcer mimicking sigmoid colon adenocarcinoma. 7272/2020


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Publication history

Received: 16/05/2020

Accepted: 01/06/2020

Online First: 20/11/2020

Published: 08/03/2021

Article Online First time: 188 days

Article editing time: 296 days


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