Year 2022 / Volume 114 / Number 1
Letter
EBV-positive mucocutaneous ulcer — Only in immunosuppressed patients?

49

DOI: 10.17235/reed.2021.8245/2021

Flor María Fernández-Gordón Sánchez, María Arranz Álvarez, Justino Jiménez Almonacid, Carmen García-Ramos García,

Abstract
We report the case of a 42-year-old male without a previous medical history who presented with hematochezia, tenesmus, and weight loss over two months. An ulcerated lesion located on the pectineal line, covering the entire circumference, was identified by colonoscopy. Histologically, there was a lymphoplasmacytic infiltrate and histiocytes with atypical Hodgkin-like lymphoid cells, and the immunohistochemistry tested positive for EBV. Random biopsies of the colorectal mucosa were normal. Thus, the patient was diagnosed with Epstein-Barr virus mucocutaneous ulcer (EBVMCU).
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References
1 Rodríguez Lorenzana P, García Gómez E, Primo Romaguera V et al. Úlcera de canal anal por virus de Epstein Barr, a propósito de un caso. CIR ESP. 2020;98(Espec Congr 1):678.
2 Ikeda T, Gion Y, Yoshino T et al. A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects. J Clin Exp Hematop. 2019;59(2):64-71. doi: 10.3960/jslrt.18039
3 Gupta I, Al Farsi H, Jabeen A, et al. Virus del papiloma humano de alto riesgo y virus de Epstein-Barr en el cáncer colorrectal y su asociación con el estado clínico-patológico. Patógenos. 2020; 9 (6): 452. Publicado el 8 de junio de 2020. Doi: 10.3390 / patógenos9060452
4 Makielski KR, Lee D, Lorenz LD, et al. Human papillomavirus promotes Epstein-Barr virus maintenance and lytic reactivation in immortalized oral keratinocytes. Virology. 2016;495:52-62. doi:10.1016/j.virol.2016.05.005
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Fernández-Gordón Sánchez F, Arranz Álvarez M, Jiménez Almonacid J, García-Ramos García C. EBV-positive mucocutaneous ulcer — Only in immunosuppressed patients?. 8245/2021


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Publication history

Received: 29/07/2021

Accepted: 02/08/2021

Online First: 02/09/2021

Published: 10/01/2022

Article Online First time: 35 days

Article editing time: 165 days


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