Year 2021 / Volume 113 / Number 1
Review
Inflammatory bowel disease and solid organ transplantation

60-64

DOI: 10.17235/reed.2020.7361/2020

María del Pilar Martínez Montiel, Begoña Casis Herce,

Abstract
The population of patients with inflammatory bowel disease (IBD) and solid organ transplant (SOT) is increasing. Two clinical scenarios exist, recurrence of pre-existing IBD, which is more common, and de novo development of IBD, with a much higher incidence than in the general population. Their clinical course differs and may have a negative impact on the graft in both cases. The pathophysiological mechanisms remain unknown and no specific treatment recommendations are available. The combined effect of biologic therapy against IBD and immunosuppressive therapy against a potential rejection means that close monitoring is mandatory to identify infection, autoimmune events and malignancies. The colorectal cancer (CRC) rate is higher in this population. The group at greatest risk are patients with IBD undergoing liver transplantation (LT) for primary sclerosing cholangitis (PSC).
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Publication history

Received: 22/06/2020

Accepted: 29/07/2020

Online First: 25/11/2020

Published: 11/01/2021

Article revision time: 19 days

Article Online First time: 156 days

Article editing time: 203 days


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