Year 2022 / Volume 114 / Number 4
Letter
Ertapenem neurotoxicity in liver transplantation

240-241

DOI: 10.17235/reed.2021.8469/2021

Sara Martínez Delgado, Alejandro Mínguez Sabater, Pablo Ladrón Abia, María Victoria Aguilera Sancho-Tello, María García Eliz, Isabel Conde,

Abstract
Carbapenems are antibiotics of the cephalosporin family with a good penetrance into the central nervous system. Neurotoxicity is a rare adverse effect, most often associated with imipenem (0.4-10 %) and unusual with ertapenem. It usually presents as seizures, although encephalopathy or hallucinations may develop. However, a recent large study (n = 544) found neurotoxicity associated to the use of ertapenem with an incidence of 4.6 %. There were associated factors such as advanced age or renal dysfunction (ertapenem has a renal metabolism level of 80 %).
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References
1. Adams R, Chopr P, Miranda R. et al Ertapenem-induced encephalopathy. BMJ Case Reports CP 2020;13
2. Hanna RM, Sun SF, Gaynor P. A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient. Antibiotics (Basel). 2018;8(1):1. 2018 Dec 22.
3. Sutton SS, Jumper M, Cook S, et al. Ertapenem-Induced Encephalopathy in a Patient With Normal Renal Function. J Investig Med High Impact Case Rep. 2017 Jan 1;5(1)
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Citation tools
Martínez Delgado S, Mínguez Sabater A, Ladrón Abia P, Aguilera Sancho-Tello M, García Eliz M, Conde I, et all. Ertapenem neurotoxicity in liver transplantation. 8469/2021


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Publication history

Received: 23/11/2021

Accepted: 30/11/2021

Online First: 22/12/2021

Published: 07/04/2022

Article Online First time: 29 days

Article editing time: 135 days


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