Year 2024 / Volume 116 / Number 2
Editorial
Liver transplantation in colorectal metastases. Is there an indication for this procedure?

59-62

DOI: 10.17235/reed.2023.9873/2023

Javier A. Cienfuegos, Gabriel Zozaya, Fernando Rotellar,

Abstract
Almost 25 % of patients with colorectal cancer present metastases at the time of diagnosis and 50 % go on to develop metastases in the course of the disease. Surgical resection is the only curative treatment although only between 20 % and 30 % of patients present resectable lesions. Although liver transplantation is contraindicated in unresectable metastases of colorectal cancer, ever since the publication of the results of a pilot study there has been renewed interest in transplantation in these patients. In two consecutive trials overall and recurrence-free 5-year survival rates of 83 % and 35 % respectively, have been reported, Currently several trials are ongoing which are expected to allow the patient selection criteria for the indication of liver transplantation to be refined.
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References
1. Siegel RL, Wagle NS, Cercek A, et al.. Colorectal cancer statistics, 2023. CA Cancer J. Clin. 2023;73:233-254
2. Hernandez Dominguez O, Yilmaz S, Steele SR. Stage IV Colorectal Cancer Management and Treatment. J. Clin Med 2023;12. Available at: http://www.ncbi.nlm.nih.gov/pubmed/36902858.
3. Tsilimigras DI, Brodt P, Clavien PA, et al. Liver metastases. Nat Rev Dis Prim. 2021;7:27
4. Kattan MW, Gönen M, Jarnagin WR, et al. A nomogram for predicting disease-specific survival after hepatic resection for metastatic colorectal cancer. Ann Surg 2008;247:282–287.
5. Cervantes A, Adam R, Roselló S, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up . Ann Oncol 2023;34:10–32.
6. Ros J, Salva F, Dopazo C, et al. Liver transplantation in metastatic colorectal cancer: are we ready for it? Br J. Canc. 2023;128:1797–1806. Available at: http://www.ncbi.nlm.nih.gov/pubmed/36879000.
7. Mühlbacher F, Huk I, Steininger R, et al. Is orthotopic liver transplantation a feasible treatment for secondary cancer of the liver? Tranplant Proc 1991:1567–8.
8. Hagness M, Foss A, Line PD, et al. Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg 2013;257:800–806.
9. Hagness M, Foss A, Egge TS, et al.. Patterns of recurrence after liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg Oncol. 2014;21:1323–1329.
10. Solheim JM, Dueland S, Line PD HM. Transplantation for Nonresectable Colorectal Liver Metastases - Long Term follow- up of the First Prospective Pilot Study. Ann Surg 2022 doi: 101097/SLA0000000000005703 Online ahead of print.
11. Maspero M, Sposito C, Virdis M, et al. Liver Transplantation for Hepatic Metastases from Colorectal Cancer: Current Knowledge and Open Issues. Cancers 2023;15. Available at: http://www.ncbi.nlm.nih.gov/pubmed/36672295.
12. Paradis C. Bias in surgical research. Ann Surg 2008;248:180–188.
13. Toso C, Pinto Marques H, Andres A, et al. Liver transplantation for colorectal liver metastasis: Survival without recurrence can be achieved. Liver Transplant 2017;23:1073–1076.
14. Dueland S, Syversveen T, Solheim JM, et al. Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases. Ann Surg 2020;271:212–218.
15. Lanari J, Hagness M, Sartori A, et al. Liver transplantation versus liver resection for colorectal liver metastasis: a survival benefit analysis in patients stratified according to tumor burden score. Transpl Int 2021;34:1722–1732.
16. Hernandez-Alejandro R, Ruffolo LI, Sasaki K, et al. Recipient and Donor Outcomes after Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases. JAMA Surg 2022;157:524–530.
17. Rajendran L, Claasen M P, McGilvray I D, et al.. Toronto Management of Initially Unresectable Liver Metastases from Colorectal Cancer in a Living Donor Liver Transplant Program. J Am Coll Surg. PMID: 37130158, DOI: 10.1097/XCS.0000000000000734 Online ahead of print
18. Bonney GK, Chew CA, Lodge P, et al. Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines. Lancet Gastroenterol Hepatol. 2021;6:933–946.
19. Mazzaferro V, Sposito C, Zhou J, et al. Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular Carcinoma. Gastroenterology 2018;154:128–139.
20. Schiano TD, Bourgoise T, Rhodes R. High-risk liver transplant candidates: An ethical proposal on where to draw the line. Liver Transpl. 2015;21:607–611.
21. León RR, Rodríguez ES, Ortega AM, et al. Characteristics and outcome of incidental hepatocellular carcinoma after liver transplantation: a cohort study. Rev Esp Enferm Dig 2022;114:219–225.
22. Hainsworth JD, Meric-Bernstam F, Swanton C, et al. Targeted therapy for advanced solid tumors on the basis of molecular profiles: Results from mypathway, an open-label, phase IIA multiple basket study. J Clin Oncol 2018;36:536–542.
23. Cercek A, Lumish M, Sinopoli J, et al. PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer. N Engl J Med 2022;386:2363–2376.
24. Königsrainer A, Templin S, Capobianco I, et al. Paradigm Shift in the Management of Irresectable Colorectal Liver Metastases: Living Donor Auxiliary Partial Orthotopic Liver Transplantation in Combination with Two-stage Hepatectomy (LD-RAPID). Ann Surg 2019;270:327–332.
25. Line PD, Ruffolo LI, Toso C,et al. Liver transplantation for colorectal liver metastases: What do we need to know? Int J Surg 2020;82:87–92.
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Cienfuegos J, Zozaya G, Rotellar F. Liver transplantation in colorectal metastases. Is there an indication for this procedure?. 9873/2023


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Publication history

Received: 27/07/2023

Accepted: 31/07/2023

Online First: 04/08/2023

Published: 07/02/2024

Article Online First time: 8 days

Article editing time: 195 days


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