Year 2019 / Volume 111 / Number 10
Letter
Hemophagocytic syndrome, a diagnostic challenge in Gastroenterology

816

DOI: 10.17235/reed.2019.6200/2019

Rita Jiménez Rosales, María del Mar Martín-Rodríguez, Eduardo Redondo-Cerezo,

Abstract
Hemophagocytic lymphohistiocytosis is a syndrome of severe immune activation with macrophage and T- cell infiltration resulting in multi organ damage. We report the case of a patient successfully treated for a haemophagocytic syndrome triggered by a metastatic neoplasm of the rectum. A 57 years old man is initially presented with fever without focus. Despite of wide spectrum antibiotics he developed a multi-organ dysfunction. A bone marrow aspirate showed histiocytes that had phagocytosed hematic cells. Hemophagocytic syndrome was suspected and specific treatment was administered. The patient’s condition improved remarkably and he was discharged. Nevertheles, finally, the patient died due to a bad response to chemotherapy. Malignancies are a well known triggering of hemophagocytic lymphohistiocytosis being hematological the most commun malignancy associated. However, solid tumors are anecdotic and, to our knowledge, this case is the first one documented due only to rectal carcinoma.
Share Button
New comment
Comments
No comments for this article
References
1. Henter JI, Horne A, Arico M, et al. HLH-2004: di- agnostic and therapeutic guidelines for he- mophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007; 48: 124-131.
2. Yamada T, Ikeya T, Ogawa T, et al. A hemophagocytic syndrome-like condition after emergency colectomy for perforated colon cancer: report of a case. Surg Today. 2002; 32: 278-81.
3. Jordan MB, Allen CE, Weitzman S, et al. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011; 118: 4041-4052.
Related articles

Digestive Diseases Image

Spontaneous regression of a rectal cancer

DOI: 10.17235/reed.2023.9486/2023

Letter

Vaginal lesion as first manifestation of colorectal disease

DOI: 10.17235/reed.2022.9270/2022

Review

Inflammatory bowel disease and solid organ transplantation

DOI: 10.17235/reed.2020.7361/2020

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Letter

Medullary colorectal carcinoma. Do we really know it?

DOI: 10.17235/reed.2020.6728/2019

Letter

The rectosigmoid junction: are limits important?

DOI: 10.17235/reed.2019.5983/2018

Editorial

Colorectal cancer screening and survival

DOI: 10.17235/reed.2018.5870/2018

Letter to the Editor

Liver metastasis from colorectal cancer 12 years after liver transplantation

DOI: 10.17235/reed.2017.4507/2016

Review

Serrated lesions and serrated polyposis syndrome

DOI: 10.17235/reed.2017.4065/2015

Letter to the Editor

Endobronchial metastases of colorectal cancer

DOI: 10.17235/reed.2016.4080/2015

Citation tools
Jiménez Rosales R, Martín-Rodríguez M, Redondo-Cerezo E. Hemophagocytic syndrome, a diagnostic challenge in Gastroenterology. 6200/2019


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1074 visits.
This article has been downloaded 206 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 29/01/2019

Accepted: 02/02/2019

Online First: 23/09/2019

Published: 03/10/2019

Article Online First time: 237 days

Article editing time: 247 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology