Year 2019 / Volume 111 / Number 10
Letter
Hemophagocytic syndrome, a diagnostic challenge in Gastroenterology

816

DOI: 10.17235/reed.2019.6200/2019

Rita Jiménez Rosales, María del Mar Martín-Rodríguez, Eduardo Redondo-Cerezo,

Abstract
Hemophagocytic lymphohistiocytosis is a syndrome of severe immune activation with macrophage and T- cell infiltration resulting in multi organ damage. We report the case of a patient successfully treated for a haemophagocytic syndrome triggered by a metastatic neoplasm of the rectum. A 57 years old man is initially presented with fever without focus. Despite of wide spectrum antibiotics he developed a multi-organ dysfunction. A bone marrow aspirate showed histiocytes that had phagocytosed hematic cells. Hemophagocytic syndrome was suspected and specific treatment was administered. The patient’s condition improved remarkably and he was discharged. Nevertheles, finally, the patient died due to a bad response to chemotherapy. Malignancies are a well known triggering of hemophagocytic lymphohistiocytosis being hematological the most commun malignancy associated. However, solid tumors are anecdotic and, to our knowledge, this case is the first one documented due only to rectal carcinoma.
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References
1. Henter JI, Horne A, Arico M, et al. HLH-2004: di- agnostic and therapeutic guidelines for he- mophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007; 48: 124-131.
2. Yamada T, Ikeya T, Ogawa T, et al. A hemophagocytic syndrome-like condition after emergency colectomy for perforated colon cancer: report of a case. Surg Today. 2002; 32: 278-81.
3. Jordan MB, Allen CE, Weitzman S, et al. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011; 118: 4041-4052.
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Jiménez Rosales R, Martín-Rodríguez M, Redondo-Cerezo E. Hemophagocytic syndrome, a diagnostic challenge in Gastroenterology. 6200/2019


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Publication history

Received: 29/01/2019

Accepted: 02/02/2019

Online First: 23/09/2019

Published: 03/10/2019

Article Online First time: 237 days

Article editing time: 247 days


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