Year 2021 / Volume 113 / Number 1
Original
Can inflammatory biomarkers help in the diagnosis and prognosis of gangrenous acute cholecystitis? A prospective study

41-44

DOI: 10.17235/reed.2020.7282/2020

José Ángel Díez Ares, Rosario Martínez García, Nuria Estellés Vidagany, Nuria Peris Tomás, Manuel Planells Roig, Marta Valenzuela Gras, Tomás Ripollés González,

Abstract
The diagnosis of gangrenous acute cholecystitis represents a diagnostic challenge for the physician and is rarely identified preoperatively. We report a longitudinal prospective study in 180 patients who underwent cholecystectomy for acute cholecystitis. A ROC curve was obtained to determine the preoperative cut-off for various biomarkers (neutrophil to lymphocyte ratio [NLR], C-reactive protein [CRP], platelet to lymphocyte ratio [PLR], lactate and procalcitonin) and their association with both preoperative and postoperative findings. The area under the curve (AUC) for NLR, CRP, PLR, lactate and procalcitonin was 0.75, 0.8, 0.65 and 0.6, respectively. NLR > 5 and CRP > 100 are still independent factors for gangrene (adjusted odds ratio [OR], 2 and 2.1, respectively).
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References
1. Aydin C, Altaca G, Berber I, Tekin K, Kara M, Titiz I. Prognostic parameters for the prediction of acute gangrenous cholecystitis. Journal of hepato-biliary-pancreatic surgery [Internet]. 2006; 13(2):[155-9 pp.].
2. Fagan SP, Awad SS, Rahwan K, Hira K, Aoki N, Itani KM, et al. Prognostic factors for the development of gangrenous cholecystitis. American journal of surgery [Internet]. 2003 Nov; 186(5):[481-5 pp.].
3. Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Choi HJ, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2012;17(3):216-22.
4. Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O'Reilly DS, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. European journal of cancer (Oxford, England : 1990). 2011;47(17):2633-41.
5. T.V. K. Karthik Hareen AB, A. R. Jaswanthi. Neutrophil to lymphocyte ratio in diagnosing acute cholecystitis: a retrospective cohort study in a tertiary rural hospital. International Surgery Journal. 2017;4.
6. Beliaev AM, Marshall RJ, Booth M. C-reactive protein has a better discriminative power than white cell count in the diagnosis of acute cholecystitis. The Journal of surgical research [Internet]. 2015 Sep; 198(1):[66-72 pp.].
7. Takada T. Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis. Journal of hepato-biliary-pancreatic sciences. 2018;25(1):1-2.
8. Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Annals of surgery. 2009;250(2):187-96.
9. Charalel RA, Jeffrey RB, Shin LK. Complicated cholecystitis: the complementary roles of sonography and computed tomography. Ultrasound quarterly [Internet]. 2011 Sep; 27(3):[161-70 pp.].
10. Shapira-Rootman M, Mahamid A, Reindorp N, Nachtigal A, Zeina AR. Sonographic Diagnosis of Complicated Cholecystitis. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [Internet]. 2015 Dec; 34(12):[2231-6 pp.].
11. Bennett GL, Rusinek H, Lisi V, Israel GM, Krinsky GA, Slywotzky CM, et al. CT findings in acute gangrenous cholecystitis. AJR American journal of roentgenology [Internet]. 2002 Feb; 178(2):[275-81 pp.].
12. Zhou MW, Gu XD, Xiang JB, Chen ZY. Comparison of clinical safety and outcomes of early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a meta-analysis. TheScientificWorldJournal [Internet]. 2014 Pmc4123505]; 2014:[274516 p.].
13. Busto Bea V, Caro Patón A, Aller Dela Fuente R, González Sagrado M, García-Alonso FJ, Pérez-Miranda Castillo M. Acute calculous cholecystitis: a real-life management study in a tertiary teaching hospital. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 2019;111(9):667-71.
14. Revel L, Lubrano J, Badet N, Manzoni P, Degano SV, Delabrousse E. Preoperative diagnosis of gangrenous acute cholecystitis: usefulness of CEUS. Abdominal imaging [Internet]. 2014 Dec; 39(6):[1175-81 pp.].
15. Kawai R, Hata J, Manabe N, Imamura H, Iida A, Nakatou R, et al. Contrast-enhanced ultrasonography with Sonazoid for diagnosis of gangrenous cholecystitis. Journal of medical ultrasonics (2001) [Internet]. 2016 Apr; 43(2):[193-9 pp.].
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Díez Ares J, Martínez García R, Estellés Vidagany N, Peris Tomás N, Planells Roig M, Valenzuela Gras M, et all. Can inflammatory biomarkers help in the diagnosis and prognosis of gangrenous acute cholecystitis? A prospective study. 7282/2020


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Publication history

Received: 20/05/2020

Accepted: 27/05/2020

Online First: 15/10/2020

Published: 11/01/2021

Article revision time: 1 days

Article Online First time: 148 days

Article editing time: 236 days


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