Year 2022 / Volume 114 / Number 9
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Immune-mediated colitis secondary to treatment with nivolumab-ipilimumab in a patient with stage IV kidney cancer: what do we do when corticosteroids fail?

554-555

DOI: 10.17235/reed.2022.8632/2022

Manuel Sánchez Cánovas, Aurelio López Martín, Sofía Montenegro Luis, Ana Sánchez Saura,

Abstract
52-year-old male. The patient had a stage IV renal carcinoma with bone metastases. He started first-line treatment with nivolumab (3 mg/kg) associated with ipilimumab (1 mg/kg). After two cycles of treatment, the patient reported hemorrhagic diarrhoea (7 to 10 stools daily), with visceral nociceptive abdominal pain of moderate intensity and oral intolerance.
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References
1. Schneider BJ, Naidoo J, Santomasso BD, et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update. J Clin Oncol. 2021 Dec 20;39(36):4073-4126. doi: 10.1200/JCO.21.01440. Epub 2021 Nov 1. Erratum in: J Clin Oncol. 2022 Jan 20;40(3):315. PMID: 34724392.
2. Majem M, García-Martínez E, Martinez M, et al. SEOM clinical guideline for the management of immune-related adverse events in patients treated with immune checkpoint inhibitors (2019). Clin Transl Oncol. 2020 Feb;22(2):213-222. doi: 10.1007/s12094-019-02273-x. Epub 2020 Jan 28. PMID: 31993963.
Luque Carmona AM, Ontanilla-Clavijo G, Leo Carnerero E. Severe enterocolitis secondary to ipilimumab and nivolumab with an excellent response to a single dose of infliximab. Rev Esp Enferm Dig. 2020 Nov;112(11):889-890. doi: 10.17235/reed.2020.6886/2020. PMID: 33054275.
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Sánchez Cánovas M, López Martín A, Montenegro Luis S, Sánchez Saura A. Immune-mediated colitis secondary to treatment with nivolumab-ipilimumab in a patient with stage IV kidney cancer: what do we do when corticosteroids fail?. 8632/2022


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Publication history

Received: 21/01/2022

Accepted: 25/01/2022

Online First: 27/01/2022

Published: 07/09/2022

Article Online First time: 6 days

Article editing time: 229 days


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