Year 2020 / Volume 112 / Number 8
Letter
Biopsy for hepatocellular carcinoma: only occasionally

666-667

DOI: 10.17235/reed.2020.6935/2020

Javier Crespo, Álvaro Díaz González,

Abstract
We would like to highlight that the non-invasive criteria for HCC diagnosis, defined by the presence of hyperenhancement in the arterial phase (wash-in) followed by hypoenhancement (wash-out) in venous phases on MRI and/or CT, have been validated by multiple cohort studies and meta-analysis. These criteria are only applicable when the pre-test probability is high (lesions > 1 cm in patients diagnosed of liver cirrhosis or chronic hepatitis B). In addition, for an adequate use of these criteria, other processes such as active (or past) neoplasms must be ruled out. In this scenario, non-invasive criteria have repeatedly demonstrated a diagnostic specificity and positive predictive value close to 100 %. Moreover, we would like to remark the transversality in the consensus of the non-invasive diagnosis of HCC, since not only the hepatology societies recommend its use, but also the oncology and radiology ones.
Share Button
New comment
Comments
No comments for this article
References
1. Illan Varela A, (falta referencia dentro de la misma publicación)
2. Crespo J, Andrade RJ. Shadows in the current management of hepatocellular carcinoma in Spain - An embarrassing truth. Rev Esp Enferm Dig. 2019 Oct 1;111(10):727–30.
3. Forner A, Vilana R, Ayuso C , et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology. 2008 Jan;47(1):97–104.
4. Lee YJ, Lee JM, Lee JS, et al. Hepatocellular carcinoma: Diagnostic performance of multidetector CT and MR imaging-a systematic review and meta-analysis. Radiology. 2015 Apr 1;275(1):97–109.
5. Galle PR, Forner A, Llovet JM, et al. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018 Jul;69(1):182–236.
6. Heimbach J, Kulik LM, Finn R, et al. Aasld guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2017 Jan 28;
7. Vogel A, Cervantes A, Chau I, et al. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 2018 Oct 1;29(Supplement_4):iv238–55.
8. Silva MA, Hegab B, Hyde C, et al. Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis. Gut. 2008 Nov 1;57(11):1592–6.
9. Stattaus J, Kuehl H, Ladd S, S, et al. CT-guided biopsy of small liver lesions: Visibility, artifacts, and corresponding diagnostic accuracy. Cardiovasc Intervent Radiol. 2007 Sep;30(5):928–35.
10. Pinyol R, Montal R, Bassaganyas L, et al. Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial. Gut. 2018 Aug 14;gutjnl-2018-316408.
1. Illan Varela A, (falta referencia dentro de la misma publicación)
2. Crespo J, Andrade RJ. Shadows in the current management of hepatocellular carcinoma in Spain - An embarrassing truth. Rev Esp Enferm Dig. 2019 111(10):727–730.
3. Forner A, Vilana R, Ayuso C , et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology. 2008 47(1):97–104.
4. Lee YJ, Lee JM, Lee JS, et al. Hepatocellular carcinoma: Diagnostic performance of multidetector CT and MR imaging-a systematic review and meta-analysis. Radiology. 2015.275(1):97–109.
5. Galle PR, Forner A, Llovet JM, et al. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018 69(1):182–236.
6. Heimbach J, Kulik LM, Finn R, et al. Aasld guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018; 67 (1):358-380
7. Vogel A, Cervantes A, Chau I, et al. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 2018 29(Supplement_4):iv238–55.
8. Silva MA, Hegab B, Hyde C, et al. Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis. Gut. 2008 57(11):1592–6.
9. Stattaus J, Kuehl H, Ladd S, et al. CT-guided biopsy of small liver lesions: Visibility, artifacts, and corresponding diagnostic accuracy. Cardiovasc Intervent Radiol. 2007 30(5):928–35.
10. Pinyol R, Montal R, Bassaganyas L, et al. Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial. Gut. 2018 gutjnl-2018-316408.
Related articles

Editorial

Hemophilia and hepatology, back to the future

DOI: 10.17235/reed.2024.10105/2023

Review

Immunotherapy in hepatocellular carcinoma

DOI: 10.17235/reed.2022.8876/2022

Digestive Diseases Image

Giant cystic hepatocarcinoma in the absence of cirrhosis

DOI: 10.17235/reed.2021.8313/2021

Letter

Hepatocarcinoma diagnosis. Reflection is required

DOI: 10.17235/reed.2020.6845/2019

Letter

Rhabdomyolysis in a patient under treatment with sorafenib

DOI: 10.17235/reed.2020.6440/2019

Case Report

Ectopic hepatocellular carcinoma arising from the peritoneum

DOI: 10.17235/reed.2019.6408/2019

Digestive Diseases Image

Debut of an unusual liver cirrhosis

Review

New challenges in clinical research on hepatocellular carcinoma

DOI: 10.17235/reed.2015.4012/2015

Citation tools
Crespo J, Díaz González Á. Biopsy for hepatocellular carcinoma: only occasionally. 6935/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1124 visits.
This article has been downloaded 198 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 03/02/2020

Accepted: 14/02/2020

Online First: 20/07/2020

Published: 30/07/2020

Article revision time: 9 days

Article Online First time: 168 days

Article editing time: 178 days


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology