Year 2020 / Volume 112 / Number 12
Letter
Reactive perforating collagenosis: a rare side effect associated with sorafenib

960-961

DOI: 10.17235/reed.2020.7138/2020

David Vega Díez, Alba Gómez Zubiaur, Susana Medina Montalvo,

Abstract
We present the case of a patient with a debut of reactive perforating collagenosis associated with the use of Sorafenib for stage IV hepatocarcinoma, very successfully controlled with local corticotherapy and systemic antihistamines. This is an extremely rare side effect associated with this treatment, as only another eleven cases of acquired perforating dermatoses associated with Sorafenib or other multi-kinase inhibitors have been found in the medical literature. Given the unusual nature of this presentation, high clinical suspicion and a correct histopathological study are indispensable for its correct filiation and treatment
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References
1. Li Z, Gao J, Zheng SM, Wang Y et al "The efficacy of sorafenib in preventing hepatocellular carcinoma recurrence after resection: a systematic review and meta-analysis", Rev Esp Enferm Dig 2020;112(3):201-10.
2. Autier J, Escudier B, Wechsler J et al. Prospective study of the cutaneous adverse effects of sorafenib, a novel multikinase inhibitor. Arch Dermatol 2008; 144: 886–92.
3. Garcıa-Malinis AJ, del Valle Sanchez A,Sanchez-Salas MP et ak. Acquired perforating dermatosis: clinicopathological study of 31 cases, emphasizing pathogenesis and treatment. JEADV 2017; 31: 1757–63
4. Sato-Sano M, Cury-Martins J, Macarenco R et al. Perforating dermatosis associated with multikinase inhibitors: report of two cases, including one associated with lenvatinib. JDDG 2018; 1612:1610-0379: 1486-89.
5. Lederhandler M, Beasley JM, Brinster NK et al. Unusual eruption in association with sorafenib: a case of acquired perforating dermatosis, reactive perforating collagenosis type. Dermatol. Online J 2018 15;24(12)
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Vega Díez D, Gómez Zubiaur A, Medina Montalvo S. Reactive perforating collagenosis: a rare side effect associated with sorafenib. 7138/2020


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Publication history

Received: 14/04/2020

Accepted: 21/04/2020

Online First: 23/11/2020

Published: 09/12/2020

Article Online First time: 223 days

Article editing time: 239 days


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