Year 2020 / Volume 112 / Number 12
Letter
Reactive perforating collagenosis: a rare side effect associated with sorafenib

960-961

DOI: 10.17235/reed.2020.7138/2020

David Vega Díez, Alba Gómez Zubiaur, Susana Medina Montalvo,

Abstract
We present the case of a patient with a debut of reactive perforating collagenosis associated with the use of Sorafenib for stage IV hepatocarcinoma, very successfully controlled with local corticotherapy and systemic antihistamines. This is an extremely rare side effect associated with this treatment, as only another eleven cases of acquired perforating dermatoses associated with Sorafenib or other multi-kinase inhibitors have been found in the medical literature. Given the unusual nature of this presentation, high clinical suspicion and a correct histopathological study are indispensable for its correct filiation and treatment
Share Button
New comment
Comments
No comments for this article
References
1. Li Z, Gao J, Zheng SM, Wang Y et al "The efficacy of sorafenib in preventing hepatocellular carcinoma recurrence after resection: a systematic review and meta-analysis", Rev Esp Enferm Dig 2020;112(3):201-10.
2. Autier J, Escudier B, Wechsler J et al. Prospective study of the cutaneous adverse effects of sorafenib, a novel multikinase inhibitor. Arch Dermatol 2008; 144: 886–92.
3. Garcıa-Malinis AJ, del Valle Sanchez A,Sanchez-Salas MP et ak. Acquired perforating dermatosis: clinicopathological study of 31 cases, emphasizing pathogenesis and treatment. JEADV 2017; 31: 1757–63
4. Sato-Sano M, Cury-Martins J, Macarenco R et al. Perforating dermatosis associated with multikinase inhibitors: report of two cases, including one associated with lenvatinib. JDDG 2018; 1612:1610-0379: 1486-89.
5. Lederhandler M, Beasley JM, Brinster NK et al. Unusual eruption in association with sorafenib: a case of acquired perforating dermatosis, reactive perforating collagenosis type. Dermatol. Online J 2018 15;24(12)
Related articles

Editorial

Hemophilia and hepatology, back to the future

DOI: 10.17235/reed.2024.10105/2023

Digestive Diseases Image

Giant cystic hepatocarcinoma in the absence of cirrhosis

DOI: 10.17235/reed.2021.8313/2021

Letter

Biopsy for hepatocellular carcinoma: only occasionally

DOI: 10.17235/reed.2020.6935/2020

Letter

Hepatocarcinoma diagnosis. Reflection is required

DOI: 10.17235/reed.2020.6845/2019

Letter

Rhabdomyolysis in a patient under treatment with sorafenib

DOI: 10.17235/reed.2020.6440/2019

Case Report

Ectopic hepatocellular carcinoma arising from the peritoneum

DOI: 10.17235/reed.2019.6408/2019

Digestive Diseases Image

Debut of an unusual liver cirrhosis

Review

New challenges in clinical research on hepatocellular carcinoma

DOI: 10.17235/reed.2015.4012/2015

Citation tools
Vega Díez D, Gómez Zubiaur A, Medina Montalvo S. Reactive perforating collagenosis: a rare side effect associated with sorafenib. 7138/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1169 visits.
This article has been downloaded 165 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 14/04/2020

Accepted: 21/04/2020

Online First: 23/11/2020

Published: 09/12/2020

Article Online First time: 223 days

Article editing time: 239 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology