Year 2020 / Volume 112 / Number 6
Original
The relationship between integrin avß6 and HBV infection in patients with liver cirrhosis and hepatocellular carcinoma: a preliminary report

462-466

DOI: 10.17235/reed.2020.6607/2019

Zhao-Bin He, Wei-Bo Niu, Cheng Peng, Chao Gao, Hui-Jie Gao, Jun Niu,

Abstract
Objective: the aim of this study was to investigate the expression of integrin αvβ6 in normal, hepatitis B, HBV-associated cirrhosis and HBV-associated HCC liver tissues. Methods: immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) were used to study the expression of integrin αvβ6 in HBV-associated cirrhosis (n = 88), chronic hepatitis B ( n= 11), HBV-associated HCC (n = 84) and normal (n = 10) human liver tissues. Results: the expression of integrin αvβ6 was significantly upregulated in HBV-associated liver cirrhosis and the expression increased with an increase in severity of cirrhosis. Furthermore, it was moderately or weakly expressed in chronic hepatitis B and HBV-associated HCC liver tissues when compared to normal liver tissue. Conclusion: integrin αvβ6 could be a predictive marker for the progression of liver cirrhosis associated with HBV infection. Further studies are needed to determine the association between the expression of integrin αvβ6 in hepatitis B and HBV-associated HCC liver tissues.
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References
1. Sarin SK, Kumar M, Lau GK, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int 2016;10:1-98.
2. Liaw YF. Antiviral therapy of chronic hepatitis B: opportunities and challenges in Asia. J Hepatol 2009;51:403-410.
3. Bertoletti A, Le Bert N. Immunotherapy for Chronic Hepatitis B Virus Infection. Gut Liver 2018;12:497-507.
4. Bosch FX, Ribes J, Cléries R, et al. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005;9:191-211.
5. Balogh J, Victor D 3rd, Asham EH, et al. Hepatocellular carcinoma: a review. J Hepatocell Carcinoma 2016;3:41-53.
6. van Bömmel F, Berg T. Treatment of HBV related cirrhosis. Liver Int 2013;33 Suppl 1:176-181.
7. Ghany MG, Doo EC. Antiviral resistance and hepatitis B therapy. Hepatology 2009;49:S174-184.
8. Lemyze M, Dharancy S, Wallaert B. Response to exercise in patients with liver cirrhosis: implications for liver transplantation. Dig Liver Dis 2013;45:362-366.
9. Said A, Lucey MR. Liver transplantation: an update 2008. Curr Opin Gastroenterol 2008;24:339-345.
10. Zhou WC, Zhang QB, Qiao L. Pathogenesis of liver cirrhosis. World J Gastroenterol 2014;20:7312-7324.
11. Cohen-Naftaly M, Friedman SL. Current status of novel antifibrotic therapies in patients with chronic liver disease. Therap Adv Gastroenterol 2011;4:391-417.
12. Ramachandran P, Henderson NC. Antifibrotics in chronic liver disease: tractable targets and translational challenges. Lancet Gastroenterol Hepatol 2016;1:328-340.
13. Hynes RO. Integrins: bidirectional, Allosteric signaling machines. Cell 2002;110:673-687.
14. Breuss JM, Gallo J, DeLisser HM, et al. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci 1995;108:2241-2251.
15. Munger JS, Huang X, Kawakatsu H, et al. The integrin αvβ6 binds and activates latent TGF-β1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999;96:319-328.
16. Hahm K, Lukashev ME, Luo Y, et al. αvβ6 Integrin regulates renal fibrosis and inflammation in the Alport mouse. Am J Pathol 2007;170:110-125.
17. Wang B, Dolinski BM, Kikuchi N, et al. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology 2007;46:1404-1412.
18. Popov Y, Patsenker E, Stickel F, et al. Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 2008;48:453-464.
19. Batts KP, Ludwig J. Chronic hepatitis: an update on terminology and reporting. Am J Surg Pathol 1995;19:1409-1417.
20. Horan GS, Wood S, Ona V, et al. Partial inhibition of integrin α (v) β6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med 2008;177:56-65.
21. Patsenker E, Popov Y, Stickel F, et al. Inhibition of integrin αvβ6 on cholangiocytes blocks transforming growth factor-β activation and retards biliary fibrosis progression. Gastroenterology 2008;135:660-670.
22. Moutasim KA, Jenei V, Sapienza K, et al. Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol 2011;223:366-377.
23. Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med 2001;344:495-500.
24. Procopet B, Berzigotti A. Diagnosis of cirrhosis and portal hypertension: imaging, non-invasive markers of fibrosis and liver biopsy. Gastroenterol Rep (Oxf) 2017;5:79-89.
25. Cho EJ, Kim MY, Lee JH, et al. Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. PLoS One 2015;10:e0133935.
26. Zarski JP, Sturm N, Guechot J, et al; ANRS HCEP 23 Fibrostar Group. Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study. J Hepatol 2012;56:55-62.
27. Yoon YJ, Friedman SL, Lee YA. Antifibrotic Therapies: Where Are We Now? Semin Liver Dis 2016;36:87-98.
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He Z, Niu W, Peng C, Gao C, Gao H, Niu J, et all. The relationship between integrin avß6 and HBV infection in patients with liver cirrhosis and hepatocellular carcinoma: a preliminary report. 6607/2019


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Publication history

Received: 03/09/2019

Accepted: 13/12/2019

Online First: 26/05/2020

Published: 08/06/2020

Article revision time: 90 days

Article Online First time: 266 days

Article editing time: 279 days


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