Year 2020 / Volume 112 / Number 8
Original
The association of dietary β-carotene and vitamin A intake on the risk of esophageal cancer: a meta-analysis

620-626

DOI: 10.17235/reed.2020.6699/2019

Kang Li, Bo Zhang,

Abstract
Background and purpose: dietary β-carotene and vitamin A intake have shown some potential effect in the development of esophageal cancer. This meta-analysis was performed to investigate the association of β-carotene and vitamin A intake on the risk of esophageal cancer. Methods: the PubMed, Embase, Web of Science and Wanfang Med online databases were systematically searched to collect the relevant articles regarding the impact of β-carotene and vitamin A intake on esophageal cancer risk. Pooled odds ratios (OR) with 95 % confidence intervals (CI) were combined using the Review Manager Version 5.3 software. Results: this meta-analysis included 14 articles. The highest category of β-carotene intake may significantly reduce the risk of esophageal cancer compared with the lowest category (OR = 0.62, 95 % CI = 0.50-0.77). Similar significant results were found in American and European populations but not in other populations with β-carotene intake. An inverse association was found between vitamin A intake and esophageal cancer risk (OR = 0.79, 95 % CI = 0.63-0.99). No potential publication bias was detected. Conclusions: our study suggested that dietary β-carotene and vitamin A intake may reduce the risk of esophageal cancer. More relevant studies are needed to further explore this association, as there were some limitations in our analysis.
Share Button
New comment
Comments
No comments for this article
References
1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65(2):87-108.
2. Mao N, Nie S, Hong B, et al. Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. World J Surg Oncol 2016; 14(1):191.
3. Wang L, Yu X, Li J, et al. Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis. BMC Cancer 2016; 16:373.
4. Ma J, Li Q, Fang X, et al. Increased total iron and zinc intake and lower heme iron intake reduce the risk of esophageal cancer: A dose-response meta-analysis. Nutr Res 2018; 59:16-28.
5. McRae MP. The Benefits of Dietary Fiber Intake on Reducing the Risk of Cancer: An Umbrella Review of Meta-analyses. J Chiropr Med 2018; 17(2):90-96.
6. Liu W, Zhou H, Zhu Y, et al. Associations between dietary folate intake and risks of esophageal, gastric and pancreatic cancers: an overall and dose-response meta-analysis. Oncotarget 2017; 8(49):86828-86842.
7. Bo Y, Lu Y, Zhao Y, et al. Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. Int J Cancer 2016; 138(8):1843-1850.
8. Cui L, Li L, Tian Y, et al. Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis. Nutrients 2018; 10(7).
9. Ma JL, Zhao Y, Guo CY, et al. Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis. Cancer Manag Res 2018; 10:5395-5410.
10. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151(4):264-269, W264.
11. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25(9):603-605.
12. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7(3):177-188.
13. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003; 327(7414):557-560.
14. Higgins JP, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med 2004; 23(11):1663-1682.
15. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109):629-634.
16. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50(4):1088-1101.
17. Chen H, Tucker KL, Graubard BI, et al. Nutrient intakes and adenocarcinoma of the esophagus and distal stomach. Nutr Cancer 2002; 42(1):33-40.
18. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Meat intake and risk of squamous cell esophageal cancer: a case-control study in Uruguay. Int J Cancer 1999; 82(1):33-37.
19. De Stefani E, Ronco AL, Boffetta P, et al. Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutr Cancer 2006; 56(2):149-157.
20. Decarli A, Liati P, Negri E, et al. Vitamin A and other dietary factors in the etiology of esophageal cancer. Nutr Cancer 1987; 10(1-2):29-37.
21. Franceschi S, Bidoli E, Negri E, et al. Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Int J Cancer 2000; 86(5):626-631.
22. Graham S, Marshall J, Haughey B, et al. Nutritional epidemiology of cancer of the esophagus. Am J Epidemiol 1990; 131(3):454-467.
23. Ibiebele TI, Hughes MC, Nagle CM, et al. Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population. Int J Cancer 2013; 133(1):214-224.
24. Jessri M, Rashidkhani B, Hajizadeh B, et al. Macronutrients, vitamins and minerals intake and risk of esophageal squamous cell carcinoma: a case-control study in Iran. Nutr J 2011; 10:137.
25. Mayne ST, Risch HA, Dubrow R, et al. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 2001; 10(10):1055-1062.
26. Tang L, Lee AH, Xu F, et al. Fruit and vegetable consumption and risk of esophageal cancer: a case-control study in north-west China. Dis Esophagus 2014; 27(8):777-782.
27. Terry P, Lagergren J, Ye W, et al. Antioxidants and cancers of the esophagus and gastric cardia. Int J Cancer 2000; 87(5):750-754.
28. Tuyns AJ, Riboli E, Doornbos G, et al. Diet and esophageal cancer in Calvados (France). Nutr Cancer 1987; 9(2-3):81-92.
29. Tzonou A, Lipworth L, Garidou A, et al. Diet and risk of esophageal cancer by histologic type in a low-risk population. Int J Cancer 1996; 68(3):300-304.
30. Zhang ZF, Kurtz RC, Yu GP, et al. Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutr Cancer 1997; 27(3):298-309.
31. Zhang T, Chen H, Qin S, et al. The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies. Biosci Rep 2016; 36(6).
32. Yu N, Su X, Wang Z, et al. Association of Dietary Vitamin A and beta-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications. Nutrients 2015; 7(11):9309-9324.
33. Lukic M, Segec A, Segec I, et al. The impact of the vitamins A, C and E in the prevention of gastroesophageal reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma. Coll Antropol 2012; 36(3):867-872.
34. Keszei AP, Goldbohm RA, Schouten LJ, et al. Dietary N-nitroso compounds, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. Am J Clin Nutr 2013; 97(1):135-146.
Related articles

Letter

A case of achalasia associated with early esophageal cancer

DOI: 10.17235/reed.2024.10177/2023

Digestive Diseases Image

A case of esophageal histoplasmosis mimicking carcinoma on endoscopy

DOI: 10.17235/reed.2023.9167/2022

Letter to the Editor

Acute gastric dilatation after dietary violation

DOI: 10.17235/reed.2017.5111/2017

Citation tools
Li K, Zhang B. The association of dietary β-carotene and vitamin A intake on the risk of esophageal cancer: a meta-analysis. 6699/2019


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 2459 visits.
This article has been downloaded 224 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 24/10/2019

Accepted: 27/01/2020

Online First: 16/06/2020

Published: 30/07/2020

Article revision time: 93 days

Article Online First time: 236 days

Article editing time: 280 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2024 y Creative Commons. The Spanish Journal of Gastroenterology