Year 2016 / Volume 108 / Number 12
Original
Regression of gastric intestinal metaplasia after the eradication of Helicobacter pylori infection in a hospital in Mexico

770-775

DOI: 10.17235/reed.2016.4194/2016

Jaime Alberto Sánchez Cuén, Ana Bertha Irineo Cabrales, Gregorio Bernal Magaña, Felipe Peraza Garay,

Abstract
Background: Intestinal metaplasia is a precursor lesion of gastric cancer. Infection by Helicobacter pylori is the principal cause of metaplasia. While evidence of the regression of metaplasia after treatment to eradicate this infection has been demonstrated, controversy remains with regard to this subject. Objective: The objective of this study was to determine the frequency of the regression of gastric intestinal metaplasia one year after the eradication of Helicobacter pylori. Methods: A prospective longitudinal designed study was carried out. The population studied in this research consisted of patients attending the Endoscopy Unit to undergo an upper endoscopy, in whom various symptoms indicated intestinal metaplasia associated with Helicobacter pylori, and who received standard empiric triple therapy to eradicate the bacteria. An upper endoscopy was performed in which four gastric biopsy samples were taken (two from the antrum and two from the body) before and after the eradicating treatment, with the endoscopic and histological findings studied after one year of monitoring. The statistical analysis was conducted using the Fisher’s exact test and the McNemar’s test. Results: Forty-six patients were studied, of whom 20 (43.5%) were men and 26 (56.5%) were women, with an average age of 58.9 (DE 11.2). Intestinal metaplasia was found in 46 (100%) patients before treatment and in 21 (45.7%) patients post-eradication. Complete intestinal metaplasia (type I) was found in 35 patients (76.1%) before treatment and in 11 (23.9%) patients post-eradication (p = 0.000), while incomplete intestinal metaplasia (type II) was found in 10 (21.7%) patients before treatment and in 10 (21.7%) patients post-eradication. Non-atrophic chronic gastritis was found in 35 (76.1%) patients before treatment and in 32 (69.6%) patients post-eradication. Conclusions: In this study, gastric intestinal metaplasia associated with Helicobacter pylori infection showed a regression of 54.3% one year after the eradication of this microorganism. This treatment could modify the natural history of the development of gastric cancer.
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13/05/2021 22:44:27
Me interesa la información, trabajo en el sector salud y me gusta estar en revisión constante para actualizarme académicamente. Gracias


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Sánchez Cuén J, Irineo Cabrales A, Bernal Magaña G, Peraza Garay F. Regression of gastric intestinal metaplasia after the eradication of Helicobacter pylori infection in a hospital in Mexico. 4194/2016


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Publication history

Received: 05/01/2016

Accepted: 03/06/2016

Online First: 02/11/2016

Published: 30/11/2016

Article revision time: 142 days

Article Online First time: 302 days

Article editing time: 330 days


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