Year 2024 / Volume 116 / Number 10
Letter
Duodenal pseudolipomatosis. Literature review and case report of a very unusual finding

562-563

DOI: 10.17235/reed.2024.10673/2024

Alfonso Agüera Sánchez, Francisco Martínez Diaz, Inmaculada Pagán Muñoz, Matías Martínez Pérez, Purificación de los Reyes Cano Mármol, Irene Martínez Martínez, David Zaragoza Huesca, Francisco García Molina,

Abstract
Pseudolipomatosis (PL) is a rare, benign, iatrogenic condition first described in colorectal mucosa. This condition is thought to arise from gas penetration into the mucosa due to mechanical or chemical injury during endoscopy. Despite these associations and its characteristic appearence, the definitive pathogenesis remains unclear and it continues to be underrecognized by some pathologists and endoscopists, which is crucial to avoid any further unnecessary treatments. Immunohistochemistry techniques play a role in differentiating PL from similar conditions such as cystic intestinal pneumatosis, intestinal lipomatosis, or lymphangiectasia. A 70-year-old man with a family history of colon adenocarcinoma was diagnosed with duodenal pseudolipomatosis after a routine endoscopic assessment. To the best of our knowledge, there have been only two reports of PL diagnosed in the duodenum. A review of over 500 duodenal biopsies at our centre revealed that no other instances were identified, emphasizing the unusual occurrence of this particular location.
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References
1. Snover DC, Sandstad J, Hutton S. Mucosal pseudolipomatosis of the colon. Am. J. Clin. Pathol. 1985;84: 575-80. https://doi.org/10.1093/ajcp/84.5.575
2. Brevet M, Chatelain D, Bartoli E, et al. Colonic pseudolipomatosis: Clinical, endoscopical and pathological features in nine cases. Gastroenterol Clin Biol. 2006;30(1):9-13. https://doi.org/10.1016/s0399-8320(06)73071-8
3. E Silva SM, Coura M de MA, Seidler HBK, Silva SM e. Colonic Pseudolipomatosis: A Rare but Characteristic Endoscopic Condition. American Journal of Case Reports. 2022 Mar 31;23. https://doi.org/10.12659/AJCR.936045
4. Cook DS, Williams GT. Duodenal 'pseudolipomatosis'. Histopathology. 1998 Oct;33(4):394-5. https://doi.org/10.1046/j.1365-2559.1998.00333.x
5. Pallarés Manrique H, Lara C, Maraver A, Talavera A, Ramos JL. Pseudolipomatosis duodenal [Duodenal pseudolipomatosis]. Rev Esp Enferm Dig. 2002 Jan;94(1):42-3.
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Agüera Sánchez A, Martínez Diaz F, Pagán Muñoz I, Martínez Pérez M, Cano Mármol P, Martínez Martínez I, et all. Duodenal pseudolipomatosis. Literature review and case report of a very unusual finding. 10673/2024


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Publication history

Received: 22/07/2024

Accepted: 31/07/2024

Online First: 05/09/2024

Published: 09/10/2024

Article Online First time: 45 days

Article editing time: 79 days


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