Year 2018 / Volume 110 / Number 11
Original
A clinical trial comparing propofol versus propofol plus midazolam in diagnostic endoscopy of patients with a low anesthetic risk

691-698

DOI: 10.17235/reed.2018.5289/2017

Laura Julián Gómez, Ana Fuentes Coronel, Carmen López Ramos, Carlos Ochoa Sangrador, Paola Fradejas Salazar, Eva Martín Garrido, Pilar Conde Gacho, Carmen Bailador Andrés, María García-Alvarado, Gabriella Rascarachi, Rocio Castillo Trujillo, Santiago José Rodríguez Gómez,

Abstract
Background and objectives: propofol and midazolam are two of the most commonly used sedatives in upper gastrointestinal endoscopy (UGE). The objective of this study was to evaluate these two sedation regimens administered to patients who underwent an UGE with regard to security, efficiency, quality of exploration and patient response. Patients and methods: a prospective, randomized and double-blind study was performed which included 83 patients between 18 and 80 years of age of a low anesthetic risk (ASA - American Society of Anesthesiologists- I-II) who underwent a diagnostic UGE. Patients were randomized to receive sedation with either placebo plus propofol (group A) or midazolam plus propofol (group B). Results: in group A, 42 patients received a placebo bolus (saline solution) and on average up to 115 mg of propofol in boluses of 20 mg. In group B, 41 patients received 3 mg of midazolam and an average of up to 83 mg of propofol in boluses of 20 mg. There were no significant differences in the adverse effects observed in either group and all adverse events were treated conservatively. The patients in group B (midazolam plus propofol) entered the desired sedated state more quickly with no variation in the overall time of the exploration. The quality of the endoscopic evaluation was similar in both groups and the patients were equally satisfied regardless of the sedatives they received. Conclusions: the use of midazolam plus propofol as a sedative does not affect the overall exploration time, a lower dose of propofol can be used and it is as safe as administering propofol as a monotherapy while providing the same level of both exploration quality and patient approval.
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13/11/2020 20:49:57
muy bueno


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Julián Gómez L, Fuentes Coronel A, López Ramos C, Ochoa Sangrador C, Fradejas Salazar P, Martín Garrido E, et all. A clinical trial comparing propofol versus propofol plus midazolam in diagnostic endoscopy of patients with a low anesthetic risk. 5289/2017


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Publication history

Received: 30/09/2017

Accepted: 19/03/2018

Online First: 15/10/2018

Published: 30/10/2018

Article revision time: 164 days

Article Online First time: 380 days

Article editing time: 395 days


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