Year 2024 / Volume 116 / Number 12
Letter
Amyloid light chain and amyloid A protein, two types of gastrointestinal amyloidosis

734-735

DOI: 10.17235/reed.2024.10930/2024

Maki Setake, Keisuke Yonamine, Kyoko Arakaki, Akira Hokama,

Abstract
We have encountered rare cases of two types of gastrointestinal amyloidosis, amyloid light chain (AL) type and amyloid A protein (AA) type. Case 1: An 83-year-old man developed hematochezia after percutaneous coronary intervention. CT scans showed wall thickening of the colon. Colonoscopy revealed submucosal tumor-like protrusions with ulceration in the colon. Biopsies confirmed the diagnosis of colonic amyloidosis. Multiple myeloma-associated AL amyloidosis was suspected based on positive serum M-protein. Case 2: A 79-year-old woman with rheumatoid arthritis (RA) underwent esophagogastroduodenoscopy, which revealed multiple gastric erosions. Biopsies showed amyloidosis. AA amyloidosis with underlying RA was suspected.
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References
1. Hokama A, Kishimoto K, Nakamoto M, et al. Endoscopic and histopathological features of gastrointestinal amyloidosis. World J Gastrointest Endosc 2011;3:157-61. doi: 10.4253/wjge.v3.i8.157.
2. Tada S, Iida M, Yao T, et al. Endoscopic features in amyloidosis of the small intestine: clinical and morphologic differences between chemical types of amyloid protein. Gastrointest Endosc 1994;40:45-50. doi: 10.1016/s0016-5107(94)70008-7.
3. Dias E, Santos-Antunes J, Marques M, et al. Clinical and endoscopic findings in gastrointestinal amyloidosis: a single-center experience. Rev Esp Enferm Dig 2022;114:425-7. doi: 10.17235/reed.2022.8656/2022.
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Setake M, Yonamine K, Arakaki K, Hokama A. Amyloid light chain and amyloid A protein, two types of gastrointestinal amyloidosis. 10930/2024


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Publication history

Received: 10/11/2024

Accepted: 28/11/2024

Online First: 04/12/2024

Published: 13/12/2024

Article Online First time: 24 days

Article editing time: 33 days


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