Year 2007 / Volume 99 / Number 5
Original
Total enteral nutrition vs. total parenteral nutrition in patients with severe acute pancreatitis

pp. 264-269

Casas, M. / Mora, J. / Fort, E. / Aracil, C. / Busquets, D. / Galter, S. / Jáuregui, C. E. / Ayala, E. / Cardona, D. / Gich, I. / Farré, A.

Abstract
Objective: to compare the efficacy of early total enteral nutrition (TEN) vs. total parenteral nutrition (TPN) in patients with severe acute pancreatitis (SAP).

Methods: a total of 22 consecutive patients with SAP were randomized to receive TPN (group I) or TEN (group II). SAP was defined applying APACHE II score, C-reactive protein (CRP) measurements and/or Balthazar CT scan score. Acute inflammatory response (CRP, TNF-a, IL-6), visceral proteins (pre-albumin, albumin), complications (systemic inflammatory response syndrome, multiorgan failure, infections), surgical interventions, length of hospital stay and mortality were evaluated.

Results: no significant differences were found between the two groups in the APACHE II score, in CRP, TNF-a and IL-6 concentrations or in pre-albumin and albumin levels over the first 10 days. Seven patients in group I and 4 in group II suffered severe complications. Three patients in group I required surgical intervention. Length of hospital stay was alike in the two groups. Two patients from group I died in the course of the hospitalization.

Conclusions: SAP patients with TEN feeding showed a tendency towards a better outcome than patients receiving TPN.
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Casas, M. / Mora, J. / Fort, E. / Aracil, C. / Busquets, D. / Galter, S. / Jáuregui, C. E. / Ayala, E. / Cardona, D. / Gich, I. / Farré, A.. Total enteral nutrition vs. total parenteral nutrition in patients with severe acute pancreatitis. 264-269


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