Year 2023 / Volume 115 / Number 6
Letter
A retrospective analysis of 32 small and well-differentiated rectal neuroendocrine tumors with regional or distant metastasis

336-337

DOI: 10.17235/reed.2022.9273/2022

Zhijie Wang, Guozhi Yu, Li Li, Shunli Qi, Qian Liu,

Abstract
Rectal neuroendocrine neoplasms (NENs) are a group of rare and heterogeneous diseases and are classified as well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) based on histological differentiation. The patients were followed up with a median period of 32.5 (range 2-123) months and no patients were lost to follow-up. The median PFS time could not be obtained, as only less than half of the patients suffered tumor progression by the end of follow-up. The 1-year and 3-year PFS rates were 73.5% and 69.2%, respectively. The median OS was 86 months in the entire cohort. The 1-year and 3-year OS rates were 100% and 96.0%, respectively.
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References
Hrabe J. Neuroendocrine Tumors of the Appendix, Colon, and Rectum. Surg Oncol Clin N Am 2020; 29: 267-279. DOI: 10.1016/j.soc.2019.11.010.
Basuroy R, Haji A, Ramage JK, et al. Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther 2016; 44: 332-345. DOI: 10.1111/apt.13697.
Caplin M, Sundin A, Nillson O, et al. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. Neuroendocrinology 2012; 95: 88-97. DOI: 10.1159/000335594.
Anthony LB, Strosberg JR, Klimstra DS, et al. The NANETS consensus guidelines for the diagnosis and management of gastrointestinal neuroendocrine tumors (nets): well-differentiated nets of the distal colon and rectum. Pancreas 2010; 39: 767-774. DOI: 10.1097/MPA.0b013e3181ec1261.
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Wang Z, Yu G, Li L, Qi S, Liu Q. A retrospective analysis of 32 small and well-differentiated rectal neuroendocrine tumors with regional or distant metastasis. 9273/2022


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Publication history

Received: 10/10/2022

Accepted: 18/10/2022

Online First: 25/10/2022

Published: 06/06/2023

Article Online First time: 15 days

Article editing time: 239 days


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