Year 2023 / Volume 115 / Number 10
Letter
Diffuse gastric adenocarcinoma during pregnancy and genetic counseling

580-581

DOI: 10.17235/reed.2022.9412/2022

César Gutiérrez Pérez, Inmaculada Rodríguez Ledesma, Carmen Blanco Abad, Juan Luis Catoya Villa, Irene Chivato Martín-Falquina, Alicia Cuenca Zarzuela, Ana María López Muñoz,

Abstract
We present the case of a 38-year-old woman who, in the context of a 22-week gestation, was diagnosed with diffuse gastric adenocarcinoma. The age of the patient and the way in which the cancer presented itself, make genetic counseling mandatory to rule out hereditary diffuse gastric carcinoma syndrome. This rare entity, of autosomal dominant inheritance and closely linked to mutations in the CDH1 (in most cases) and CTNNA1 genes, is associated with a greater predisposition to develop malignant neoplasms of the breast and stomach. Genetic sequencing ruled out hereditary diffuse gastric cancer syndrome. Unfortunately, 24 months after the cesarean section, our patient dies.
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References
1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71(3):209-49.
2. Gamble LA, Heller T, Davis JL. Hereditary Diffuse Gastric Cancer Syndrome and the Role of CDH1: A Review. JAMA Surg 2021;156(4):387-92.
Blair VR, McLeod M, Carneiro F, et al. Hereditary diffuse gastric cancer: updated clinical practice guidelines. Lancet Oncol. 2020;21(8):e386-e397. doi:10.1016/S1470-2045(20)30219-9
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Gutiérrez Pérez C, Rodríguez Ledesma I, Blanco Abad C, Catoya Villa J, Chivato Martín-Falquina I, Cuenca Zarzuela A, et all. Diffuse gastric adenocarcinoma during pregnancy and genetic counseling. 9412/2022


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Publication history

Received: 07/12/2022

Accepted: 11/12/2022

Online First: 23/12/2022

Published: 09/10/2023

Article Online First time: 16 days

Article editing time: 306 days


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