Year 2006 / Volume 98 / Number 12
Original
Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

pp. 907-916

A. Muela Molinero, F. Jorquera Plaza, T. Ribas Ariño, R. Malagón Rojo, V. Espinel Díez B. Ballesteros del Río, J. L. Olcoz Goñi and J. A. Santos Calderón

Abstract
Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León.

Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of
patients diagnosed with a second neoplasm were analyzed.
Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first
two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN.

Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as romoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development
of MMPN. Secondary prevention is the best measure to
avoid MMPN development
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A. Muela Molinero, F. Jorquera Plaza, T. Ribas Ariño, R. Malagón Rojo, V. Espinel Díez B. Ballesteros del Río, J. L. Olcoz Goñi and J. A. Santos Calderón. Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León. 907-916


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