References
1,- Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. New Engl J Med 2014; 371: 1039-1049
2,- Koorstra JBM, Hustinx SR, Offerhaus GJA et al. Pancreatic carcinogenesis 2008; 8: 110-125
3,- Tanaka M, Fernández-del Castillo C, Adsay V et al. International consensus guidelines 2012 for the management of IPMN and MQN of the pancreas. Pancreatology 2012; 12; 183-197
4,- Gocheva V, Wang HW, Gadea BB et al. Il-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 2010; 24: 241-255
5,- Garcea G, Neal CP, Pattender CJ et al. Molecular prognostic markers in pancreatic cancer: a systematic review. Eur J Cancer 2005; 41: 2213-2236
6,- Vasiljeva O, Reinheckel T, Peters C et al. Emerging roles of cysteine cathepsins in disease and their potential as drugs targets. Curr Pharm Des 2007; 13: 387-403
7,- Turk V, Turk B, Guncar G et al. Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer. Adv Enzyme Regul 2002; 42: 285-303
8,- Turk B, Stoka V, Rozman-Pungercar J et al. Apoptotic pathways: involvement of lysosomal proteases. Biol Chem 2002; 383: 1035-1044
9,- Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest 2005; 52: 1-9
10,- Vasiljeva O, Papazoglou A, Krüger A et al. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 2006; 66: 5242-5250
11,- Aggarwal N, Sloane BF. Cathepsin B: multiple roles in cancer. Proteomics Clin Appl 2014; 8: 427-437
12,- Joyce JA, Hanahan D. Multiple roles for cysteine cathepsins in cancer. Cell Cycle 2004; 3: 1516-1519
13,- Reinheckel T, Peters C, Krüger A et al. Differential impact of cysteine cathepsins on genetic mouse models of the novo carcinogenesis: cathepsin B as emerging therapeutic target. Front Pharmacol 2012; 3: 133
14,- Sulpizio S, Franceschini N, Piatelli A et al. Cathepsins and pancreatic cancer: the 2012 update. Pancreatology 2012; 12: 395-401
15,- Hwang JH; Lee SH, Lee KH et al. Cathepsin B is a target of hedgehog signaling in pancreatic cancer. Cancer Lett 2009; 273: 266-272
16,- Zhang C, Sun J, Liu D et al. Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice. Chin Med J 2009; 122: 2489-2496
17,- Joyce JA, Baruch A, Chehade K et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 2004; 5: 443-453
18,- Gocheva V, Chen X, Peters C et al. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem 2010; 391: 937-945
19,- Dumartin L, Whitwman HJ, Weeks ME et al. AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B y D. Cancer Res 2011; 71: 7091-7102
20,- Ogbomo SN, Shi W, Wagh NK et al. 177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: syntesis, characterization and preliminary in vivo investigation in a pancreatic cancer model. Nucl Med Biol 2013; 40: 606-617
21,- Whiteman HJ, Weeks ME, Dowen SE et al. The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D. Cancer Res 2007; 67: 8633-8642
22,- Gopinathan A, de Nicola G, Frese K et al. Cathepsin B promotes the progression of pancreatic ductal carcinoma in mice. Gut 2012;61:877-884
23,- Paciucci R, Berrozpe G, Torà M et al. Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using substractive hybridation. FEBS Letters 1996; 385: 72-76
24.- Niedergethmann M, Wostbrock B, Sturm JW et al. Pancreatic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma. Pancreas 2004; 29: 204-211
25,- Niedergethmann M; Hildenbrand R, Wolf G et al. Angiogenesis and cathepsin exxpression are prognostic factors in pancreatic adenocarcinoma after curative resection. Int J Pancreatol 2000; 28: 31-39
26,- Chen R, Brentnall T, Pan S et al. Quantitative proteomics analysis reveals that proteins differentially expressed in chronic are also frequently involved in pancreatic cancer. Mol Cell Proteomics 2007; 6: 1331-1342
27,- Ohta T, Terada T, Nagakawa T et al. Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastasic lesions. Br J Cancer 1994; 69: 152-156
28.- Cruz-Monserrate Z, Abd-Elgaliel W, Grote T et al. Detection of pancreatic tumours and precursor lesions by cathepsin E activity in mouse models. Gut 2012; 61; 1315-1322
29,- Eser S, Messer M, Eser P et al. In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. PNAS 2011; 108: 9945-9950
30,- Von Burstin J, Eser S, Seidler B et al. Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. Int J Cancer 2008; 123: 2138-2147
31,- Leto G, Tumminello FM, Pizzolanti G et al. Lysosomal aspartic and cysteine proteinases serum levels in patients with pancreatic cancer or pancreatitis. Pancreas 1997; 14: 22-27
32,- Tumminello FM, Leto G, Pizzolanti G et al. Cathepsin D, B and L circulating levels as prognostic markers of malignant progression. Anticancer res 1996; 16: 2315-2319
33,- Park HD, Kang ES, Kim JW et al. Serum CA 19-9, cathepsin D, and matrix metalloproteinase-7 as a diagnostic panel for pancreatic ductal adenocarcinoma. Proteomics 2012; 12: 3590-3597
34,- Uno K, Azuma T, Nakajima M et al. Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma. J Gastroenterol Hepatol 2000; 15: 1333-1338
35,- Azuma T, Hirai M, Ito S et al. Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report. Int J Cancer 1996; 67: 492-497
36,- Terris B, Blaveri E, Crnogorac-Jurcevic T et al. Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. Am J pathol 2002; 160: 1745-1754
37,- Mizuno N, Hara K, Hijioka S et al. Current concept of enscopic ultrasound-guided fine needle aspiration for pancreatic cancer. Pancreatology. 2011;11 Suppl 2:40-6
38,- Abd-Elgaliel W, Cruz-Monserrate Z, Wang H et al. Pancreatic cancer-associated cathepsin E as a drug activator. J Control Release 2013; 167: 221-227